Insulin and Exendin-4 Reduced Mutated Huntingtin Accumulation in Neuronal Cells

Insulin and Exendin-4 Reduced Mutated Huntingtin Accumulation in Neuronal Cells

Patients with diabetes mellitus (DM) are more prone to develop cognitive decline and neurodegenerative diseases. A pathological association between an autosomal dominant neurological disorder caused by brain accumulation in mutated huntingtin (mHTT), known as Huntington disease (HD), and DM, has bee...

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Bibliographic Details
Main Authors: Silvia Rea, David Della-Morte, Francesca Pacifici, Barbara Capuani, Donatella Pastore, Andrea Coppola, Roberto Arriga, Aikaterini Andreadi, Giulia Donadel, Nicola Di Daniele, Alfonso Bellia, Davide Lauro
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Huntington disease
neuronal survival
insulin
exendin-4
mutated huntingtin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00779/full

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