Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid
Goitre is an enlargement of thyroid gland which can be associated with primary thyroid disorders or stimulation of the gland by hormones and other factors. In Indonesia and especially in Bali, increase of Thyroid Carcinoma cases had been associated with either endemic or non endemic goiter. Goitre i...
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| Format: | Article |
| Language: | English |
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Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa
2016-11-01
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| Series: | WMJ (Warmadewa Medical Journal) |
| Subjects: | |
| Online Access: | https://www.ejournal.warmadewa.ac.id/index.php/warmadewa_medical_journal/article/view/27 |
| _version_ | 1797650716440920064 |
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| author | Ni Wayan Armerinayanti |
| author_facet | Ni Wayan Armerinayanti |
| author_sort | Ni Wayan Armerinayanti |
| collection | DOAJ |
| description | Goitre is an enlargement of thyroid gland which can be associated with primary thyroid disorders or stimulation of the gland by hormones and other factors. In Indonesia and especially in Bali, increase of Thyroid Carcinoma cases had been associated with either endemic or non endemic goiter. Goitre increases 2.5 fold risk of thyroid carcinoma. Goitre may cause diffuse and nodular hyperplasia (either single or multiple nodules). Clonal analysis has been discovered that hyperplasia is considered to be polyclonal proliferation. Monoclonal alterations had also been found in a subset of thyroid nodules that were previously considered hyperplastic. Alterations of polyclonal to monoclonal pattern was considered as interaction between past history of hyperplastic lesion and genetic predisposition which furthermore forming mutagenic environment such as increases of cell proliferation and also free radicals induce- somatic mutation. Iodine supplementation on endemic goiter related with radioactive iodine content which damaging DNA sequences in the form of RET-TRK rearrangement. |
| first_indexed | 2024-03-11T16:05:28Z |
| format | Article |
| id | doaj.art-c4da59dce2084716b8425432fad3eb35 |
| institution | Directory Open Access Journal |
| issn | 2527-4627 2579-9010 |
| language | English |
| last_indexed | 2024-03-11T16:05:28Z |
| publishDate | 2016-11-01 |
| publisher | Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa |
| record_format | Article |
| series | WMJ (Warmadewa Medical Journal) |
| spelling | doaj.art-c4da59dce2084716b8425432fad3eb352023-10-25T04:18:16ZengFakultas Kedokteran dan Ilmu Kesehatan, Universitas WarmadewaWMJ (Warmadewa Medical Journal)2527-46272579-90102016-11-01124250https://doi.org/10.22225/wmj.1.2.27.42-50Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid Ni Wayan Armerinayanti 0Bagian Patologi Anatomi Fakultas Kedokteran dan Ilmu Kesehatan Universitas WarmadewaGoitre is an enlargement of thyroid gland which can be associated with primary thyroid disorders or stimulation of the gland by hormones and other factors. In Indonesia and especially in Bali, increase of Thyroid Carcinoma cases had been associated with either endemic or non endemic goiter. Goitre increases 2.5 fold risk of thyroid carcinoma. Goitre may cause diffuse and nodular hyperplasia (either single or multiple nodules). Clonal analysis has been discovered that hyperplasia is considered to be polyclonal proliferation. Monoclonal alterations had also been found in a subset of thyroid nodules that were previously considered hyperplastic. Alterations of polyclonal to monoclonal pattern was considered as interaction between past history of hyperplastic lesion and genetic predisposition which furthermore forming mutagenic environment such as increases of cell proliferation and also free radicals induce- somatic mutation. Iodine supplementation on endemic goiter related with radioactive iodine content which damaging DNA sequences in the form of RET-TRK rearrangement.https://www.ejournal.warmadewa.ac.id/index.php/warmadewa_medical_journal/article/view/27goitrepredisposethyroid carcinoma |
| spellingShingle | Ni Wayan Armerinayanti Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid WMJ (Warmadewa Medical Journal) goitre predispose thyroid carcinoma |
| title | Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid |
| title_full | Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid |
| title_fullStr | Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid |
| title_full_unstemmed | Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid |
| title_short | Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid |
| title_sort | goiter sebagai faktor predisposisi karsinoma tiroid |
| topic | goitre predispose thyroid carcinoma |
| url | https://www.ejournal.warmadewa.ac.id/index.php/warmadewa_medical_journal/article/view/27 |
| work_keys_str_mv | AT niwayanarmerinayanti goitersebagaifaktorpredisposisikarsinomatiroid |