[4+2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones

[4+2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones

Novel hydantion and thiohydantoin-based spiro-compounds were prepared via theDiels–Alder reactions between 5-methylidene-hydantoins or 5-methylidene-2-thiohydantoins and 1,3-dienes (cyclopentadiene, cyclohexadiene, 2,3-dimethylbutadiene, isoprene). It was shown that the cycloaddition reactions proce...

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Bibliographic Details
Main Authors: Dmitry E. Shybanov, Maxim E. Kukushkin, Yanislav S. Hrytseniuk, Yuri K. Grishin, Vitaly A. Roznyatovsky, Viktor A. Tafeenko, Dmitry A. Skvortsov, Nikolai V. Zyk, Elena K. Beloglazkina
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
spiro-compounds
hydantoins
2-thiohydantoins
Diels–Alder reaction
[4+2]-cycloaddition
cytotoxicity
Online Access:https://www.mdpi.com/1422-0067/24/5/5037

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https://www.mdpi.com/1422-0067/24/5/5037

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