The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation
The article presents the results of an investigation of the frequency of genetic markers of the folate cycle in 24 neonates with the hypotrophic or hypoplastic types of intrauterine growth retardation (IUGR). The investigators examined the polymorphisms of the methylenetetrahydrofolate reductase (MT...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2016-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/193 |
| _version_ | 1797875333121179648 |
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| author | A. N. Ni T. Yu. Fadeeva T. G. Vasilyeva S. N. Shishatskaya |
| author_facet | A. N. Ni T. Yu. Fadeeva T. G. Vasilyeva S. N. Shishatskaya |
| author_sort | A. N. Ni |
| collection | DOAJ |
| description | The article presents the results of an investigation of the frequency of genetic markers of the folate cycle in 24 neonates with the hypotrophic or hypoplastic types of intrauterine growth retardation (IUGR). The investigators examined the polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene, such as S677S, C677T, and T677T, the methionine synthase (MTR) gene, such as A2756A, A2756G, and G2756G, and the methionine synthase reductase (MTRR) gene, such as G66G, G66A, and A66A. The analysis established an association of the occurrence of IUGR in neonates with MTHFR T677T, MTR G2756G, and MTRR A66A polymorphisms; this is especially relevant in the hypotrophic type of IUGR and in boys. Identification of risk groups and genetic analysis of folic acid metabolism allow the choice of an effective package of measures to prevent IUGR. |
| first_indexed | 2024-04-10T01:45:59Z |
| format | Article |
| id | doaj.art-c4dbcefa3fd24b458c98334d6eeb60ad |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:45:59Z |
| publishDate | 2016-03-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-c4dbcefa3fd24b458c98334d6eeb60ad2023-03-13T09:12:40ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282016-03-016036366186The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardationA. N. Ni0T. Yu. Fadeeva1T. G. Vasilyeva2S. N. Shishatskaya3ГБОУ ВПО «Тихоокеанский государственный медицинский университет»ГБОУ ВПО «Тихоокеанский государственный медицинский университет»ГАУЗ «Краевой клинический центр специализированных видов медицинской помощи», ВладивостокГБОУ ВПО «Тихоокеанский государственный медицинский университет»The article presents the results of an investigation of the frequency of genetic markers of the folate cycle in 24 neonates with the hypotrophic or hypoplastic types of intrauterine growth retardation (IUGR). The investigators examined the polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene, such as S677S, C677T, and T677T, the methionine synthase (MTR) gene, such as A2756A, A2756G, and G2756G, and the methionine synthase reductase (MTRR) gene, such as G66G, G66A, and A66A. The analysis established an association of the occurrence of IUGR in neonates with MTHFR T677T, MTR G2756G, and MTRR A66A polymorphisms; this is especially relevant in the hypotrophic type of IUGR and in boys. Identification of risk groups and genetic analysis of folic acid metabolism allow the choice of an effective package of measures to prevent IUGR.https://www.ped-perinatology.ru/jour/article/view/193плодноворожденныйзадержка внутриутробного развитиягены mthfrmtrmtrrфолатный цикл |
| spellingShingle | A. N. Ni T. Yu. Fadeeva T. G. Vasilyeva S. N. Shishatskaya The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation Rossijskij Vestnik Perinatologii i Pediatrii плод новорожденный задержка внутриутробного развития гены mthfr mtr mtrr фолатный цикл |
| title | The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation |
| title_full | The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation |
| title_fullStr | The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation |
| title_full_unstemmed | The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation |
| title_short | The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation |
| title_sort | frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation |
| topic | плод новорожденный задержка внутриутробного развития гены mthfr mtr mtrr фолатный цикл |
| url | https://www.ped-perinatology.ru/jour/article/view/193 |
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