Hypothesis of COVID-19 therapy with sildenafil
Backgound: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible nitric o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2020;volume=11;issue=1;spage=76;epage=76;aulast=Mario |
| _version_ | 1818518936007737344 |
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| author | Limodio Mario Menicagli Roberto Limodio Marta Casotti Maria Teresa Menicagli Laura |
| author_facet | Limodio Mario Menicagli Roberto Limodio Marta Casotti Maria Teresa Menicagli Laura |
| author_sort | Limodio Mario |
| collection | DOAJ |
| description | Backgound: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible nitric oxide synthase (iNOS). Excess production of this compound occurs in COVID-19 resulting in inflammatory cascade and thromboembolism. We intend to propose the use of sildenafil to reduce this production. Method: The analysis of biochemical pathways shows that viral infection produces a high amount of nitric oxide (NO), with an acute inflammatory process. Results: In the case of COVID-19 infection we verified that numerous biochemical processes activate a cascade of inflammatory processes through the activation of iNOS with uncontrolled generation of (NO). Conclusions: iNOS is the cause of damage to host cells with a consequent pulmonary thromboembolic lung phenomenon in a contest of interstitial pneumonia. This study proposes the use of sildenafil to counter the inflammatory cascade and thromboembolic episodes. |
| first_indexed | 2024-12-11T01:17:05Z |
| format | Article |
| id | doaj.art-c4dc1af3a0454d96a8a7529b3037b211 |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-12-11T01:17:05Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-c4dc1af3a0454d96a8a7529b3037b2112022-12-22T01:25:51ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132020-01-01111767610.4103/ijpvm.IJPVM_258_20Hypothesis of COVID-19 therapy with sildenafilLimodio MarioMenicagli RobertoLimodio MartaCasotti Maria TeresaMenicagli LauraBackgound: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible nitric oxide synthase (iNOS). Excess production of this compound occurs in COVID-19 resulting in inflammatory cascade and thromboembolism. We intend to propose the use of sildenafil to reduce this production. Method: The analysis of biochemical pathways shows that viral infection produces a high amount of nitric oxide (NO), with an acute inflammatory process. Results: In the case of COVID-19 infection we verified that numerous biochemical processes activate a cascade of inflammatory processes through the activation of iNOS with uncontrolled generation of (NO). Conclusions: iNOS is the cause of damage to host cells with a consequent pulmonary thromboembolic lung phenomenon in a contest of interstitial pneumonia. This study proposes the use of sildenafil to counter the inflammatory cascade and thromboembolic episodes.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2020;volume=11;issue=1;spage=76;epage=76;aulast=Mariocovid-19nitric oxidesildenafil citrate |
| spellingShingle | Limodio Mario Menicagli Roberto Limodio Marta Casotti Maria Teresa Menicagli Laura Hypothesis of COVID-19 therapy with sildenafil International Journal of Preventive Medicine covid-19 nitric oxide sildenafil citrate |
| title | Hypothesis of COVID-19 therapy with sildenafil |
| title_full | Hypothesis of COVID-19 therapy with sildenafil |
| title_fullStr | Hypothesis of COVID-19 therapy with sildenafil |
| title_full_unstemmed | Hypothesis of COVID-19 therapy with sildenafil |
| title_short | Hypothesis of COVID-19 therapy with sildenafil |
| title_sort | hypothesis of covid 19 therapy with sildenafil |
| topic | covid-19 nitric oxide sildenafil citrate |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2020;volume=11;issue=1;spage=76;epage=76;aulast=Mario |
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