The Impact of Persistent Noise Exposure under Inflammatory Conditions
The aim of this study was to investigate the impact of noise exposure in an intensive care unit (ICU) environment on the development of postoperative delirium in a mouse model that mimics the ICU environment. Additionally, we aimed to identify the underlying mechanisms contributing to delirium and p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/14/2067 |
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| author | Inja Cho Jeongmin Kim Seungho Jung So Yeon Kim Eun Jung Kim Sungji Choo Eun Hee Kam Bon-Nyeo Koo |
| author_facet | Inja Cho Jeongmin Kim Seungho Jung So Yeon Kim Eun Jung Kim Sungji Choo Eun Hee Kam Bon-Nyeo Koo |
| author_sort | Inja Cho |
| collection | DOAJ |
| description | The aim of this study was to investigate the impact of noise exposure in an intensive care unit (ICU) environment on the development of postoperative delirium in a mouse model that mimics the ICU environment. Additionally, we aimed to identify the underlying mechanisms contributing to delirium and provide evidence for reducing the risk of delirium. In this study, to mimic an ICU environment, lipopolysaccharide (LPS)-injected sepsis mouse models were exposed to a 75 dB noise condition. Furthermore, we assessed neurobehavioral function and observed the level of neuroinflammatory response and blood–brain barrier (BBB) integrity in the hippocampal region. The LPS-injected sepsis mouse model exposed to noise exhibited increased anxiety-like behavior and cognitive impairment. Moreover, severe neuroinflammation and BBB disruption were detected in the hippocampal region. This study provides insights suggesting that persistent noise exposure under systemic inflammatory conditions may cause cognitive dysfunction and anxiety- like behavior via the mediation of BBB disruption and neuroinflammation. As a result, we suggest that the detailed regulation of noise exposure may be required to prevent the development of postoperative delirium. |
| first_indexed | 2024-03-11T01:02:02Z |
| format | Article |
| id | doaj.art-c4dc8bcc9cc3492eb56f3ff10bb4204d |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T01:02:02Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-c4dc8bcc9cc3492eb56f3ff10bb4204d2023-11-18T19:33:31ZengMDPI AGHealthcare2227-90322023-07-011114206710.3390/healthcare11142067The Impact of Persistent Noise Exposure under Inflammatory ConditionsInja Cho0Jeongmin Kim1Seungho Jung2So Yeon Kim3Eun Jung Kim4Sungji Choo5Eun Hee Kam6Bon-Nyeo Koo7Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaThe aim of this study was to investigate the impact of noise exposure in an intensive care unit (ICU) environment on the development of postoperative delirium in a mouse model that mimics the ICU environment. Additionally, we aimed to identify the underlying mechanisms contributing to delirium and provide evidence for reducing the risk of delirium. In this study, to mimic an ICU environment, lipopolysaccharide (LPS)-injected sepsis mouse models were exposed to a 75 dB noise condition. Furthermore, we assessed neurobehavioral function and observed the level of neuroinflammatory response and blood–brain barrier (BBB) integrity in the hippocampal region. The LPS-injected sepsis mouse model exposed to noise exhibited increased anxiety-like behavior and cognitive impairment. Moreover, severe neuroinflammation and BBB disruption were detected in the hippocampal region. This study provides insights suggesting that persistent noise exposure under systemic inflammatory conditions may cause cognitive dysfunction and anxiety- like behavior via the mediation of BBB disruption and neuroinflammation. As a result, we suggest that the detailed regulation of noise exposure may be required to prevent the development of postoperative delirium.https://www.mdpi.com/2227-9032/11/14/2067noise exposureinflammationneuroinflammationcognitive impairmentanxiety-like behaviorblood–brain barrier |
| spellingShingle | Inja Cho Jeongmin Kim Seungho Jung So Yeon Kim Eun Jung Kim Sungji Choo Eun Hee Kam Bon-Nyeo Koo The Impact of Persistent Noise Exposure under Inflammatory Conditions Healthcare noise exposure inflammation neuroinflammation cognitive impairment anxiety-like behavior blood–brain barrier |
| title | The Impact of Persistent Noise Exposure under Inflammatory Conditions |
| title_full | The Impact of Persistent Noise Exposure under Inflammatory Conditions |
| title_fullStr | The Impact of Persistent Noise Exposure under Inflammatory Conditions |
| title_full_unstemmed | The Impact of Persistent Noise Exposure under Inflammatory Conditions |
| title_short | The Impact of Persistent Noise Exposure under Inflammatory Conditions |
| title_sort | impact of persistent noise exposure under inflammatory conditions |
| topic | noise exposure inflammation neuroinflammation cognitive impairment anxiety-like behavior blood–brain barrier |
| url | https://www.mdpi.com/2227-9032/11/14/2067 |
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