Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus
Abstract Background Inappropriate weight gain may increase the risk of gestational diabetes mellitus (GDM). However, the relationship between pre-pregnancy body mass index (BMI), weight gain, and GDM has not been precisely quantified. This study aimed to explore whether gestational weight gain playe...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-04-01
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| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-022-00203-5 |
| _version_ | 1828262238174052352 |
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| author | Shuang Zhang Jingyu Wang Fang Xu Juhong Yang Yongzhang Qin Junhong Leng Nan Li Jia Guo Xiaochen Li Zhong’ai Gao Xiaofang Shen Hui Gao Baocheng Chang Hong Zhu |
| author_facet | Shuang Zhang Jingyu Wang Fang Xu Juhong Yang Yongzhang Qin Junhong Leng Nan Li Jia Guo Xiaochen Li Zhong’ai Gao Xiaofang Shen Hui Gao Baocheng Chang Hong Zhu |
| author_sort | Shuang Zhang |
| collection | DOAJ |
| description | Abstract Background Inappropriate weight gain may increase the risk of gestational diabetes mellitus (GDM). However, the relationship between pre-pregnancy body mass index (BMI), weight gain, and GDM has not been precisely quantified. This study aimed to explore whether gestational weight gain played a mediating role between pre-pregnancy BMI and GDM and whether the mediating effect was sex specific. Methods This study established a population-based observational cohort to assess weight gain in pregnant women. Mediation analyses were performed to quantify whether weight gain mediated the association between pre-pregnancy BMI and GDM. Results A total of 67,777 pregnant women were included in the final analysis, among whom 6751 (10.0%) were diagnosed with GDM. We verified that both pre-pregnancy BMI and weight gain were associated with GDM, and that BMI negatively contributed to weight gain. We also found that weight gain had a significant mediating effect on the relationship between pre-pregnancy BMI and GDM (Z a × Z b confidence intervals [CIs] 0.00234–0.00618). Furthermore, the effect was sex-specific, in that it was only significant in overweight women carrying female fetuses (Z a × Z b CIs 0.00422–0.01977), but not male fetuses (Z a × Z b CIs −0.00085 to 0.01236). Conclusions Weight gain during pregnancy had a fetal sex-specific mediating effect between pre-pregnancy BMI and GDM. |
| first_indexed | 2024-04-13T03:51:35Z |
| format | Article |
| id | doaj.art-c4dcb5246b9d4ec7b31f5dfb1897c01e |
| institution | Directory Open Access Journal |
| issn | 2044-4052 |
| language | English |
| last_indexed | 2024-04-13T03:51:35Z |
| publishDate | 2022-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Nutrition & Diabetes |
| spelling | doaj.art-c4dcb5246b9d4ec7b31f5dfb1897c01e2022-12-22T03:03:48ZengNature Publishing GroupNutrition & Diabetes2044-40522022-04-011211810.1038/s41387-022-00203-5Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitusShuang Zhang0Jingyu Wang1Fang Xu2Juhong Yang3Yongzhang Qin4Junhong Leng5Nan Li6Jia Guo7Xiaochen Li8Zhong’ai Gao9Xiaofang Shen10Hui Gao11Baocheng Chang12Hong Zhu13NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityTianjin Women’s and Children’s Health CenterTianjin Women’s and Children’s Health CenterTianjin Women’s and Children’s Health CenterNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityDepartment of Obstetrics and Gynaecology, Beijing Tiantan Hospital, Capital Medical UniversityNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin Medical UniversityAbstract Background Inappropriate weight gain may increase the risk of gestational diabetes mellitus (GDM). However, the relationship between pre-pregnancy body mass index (BMI), weight gain, and GDM has not been precisely quantified. This study aimed to explore whether gestational weight gain played a mediating role between pre-pregnancy BMI and GDM and whether the mediating effect was sex specific. Methods This study established a population-based observational cohort to assess weight gain in pregnant women. Mediation analyses were performed to quantify whether weight gain mediated the association between pre-pregnancy BMI and GDM. Results A total of 67,777 pregnant women were included in the final analysis, among whom 6751 (10.0%) were diagnosed with GDM. We verified that both pre-pregnancy BMI and weight gain were associated with GDM, and that BMI negatively contributed to weight gain. We also found that weight gain had a significant mediating effect on the relationship between pre-pregnancy BMI and GDM (Z a × Z b confidence intervals [CIs] 0.00234–0.00618). Furthermore, the effect was sex-specific, in that it was only significant in overweight women carrying female fetuses (Z a × Z b CIs 0.00422–0.01977), but not male fetuses (Z a × Z b CIs −0.00085 to 0.01236). Conclusions Weight gain during pregnancy had a fetal sex-specific mediating effect between pre-pregnancy BMI and GDM.https://doi.org/10.1038/s41387-022-00203-5 |
| spellingShingle | Shuang Zhang Jingyu Wang Fang Xu Juhong Yang Yongzhang Qin Junhong Leng Nan Li Jia Guo Xiaochen Li Zhong’ai Gao Xiaofang Shen Hui Gao Baocheng Chang Hong Zhu Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus Nutrition & Diabetes |
| title | Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus |
| title_full | Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus |
| title_fullStr | Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus |
| title_full_unstemmed | Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus |
| title_short | Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus |
| title_sort | sex specific mediating effect of gestational weight gain between pre pregnancy body mass index and gestational diabetes mellitus |
| url | https://doi.org/10.1038/s41387-022-00203-5 |
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