Extreme inbreeding in a European ancestry sample from the contemporary UK population
Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other compl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11724-6 |
| _version_ | 1819129289341140992 |
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| author | Loic Yengo Naomi R. Wray Peter M. Visscher |
| author_facet | Loic Yengo Naomi R. Wray Peter M. Visscher |
| author_sort | Loic Yengo |
| collection | DOAJ |
| description | Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits. |
| first_indexed | 2024-12-22T08:41:21Z |
| format | Article |
| id | doaj.art-c4de637591d1426c8bf1b0307e7f96ad |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:41:21Z |
| publishDate | 2019-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c4de637591d1426c8bf1b0307e7f96ad2022-12-21T18:32:13ZengNature PortfolioNature Communications2041-17232019-09-0110111110.1038/s41467-019-11724-6Extreme inbreeding in a European ancestry sample from the contemporary UK populationLoic Yengo0Naomi R. Wray1Peter M. Visscher2Institute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandMating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.https://doi.org/10.1038/s41467-019-11724-6 |
| spellingShingle | Loic Yengo Naomi R. Wray Peter M. Visscher Extreme inbreeding in a European ancestry sample from the contemporary UK population Nature Communications |
| title | Extreme inbreeding in a European ancestry sample from the contemporary UK population |
| title_full | Extreme inbreeding in a European ancestry sample from the contemporary UK population |
| title_fullStr | Extreme inbreeding in a European ancestry sample from the contemporary UK population |
| title_full_unstemmed | Extreme inbreeding in a European ancestry sample from the contemporary UK population |
| title_short | Extreme inbreeding in a European ancestry sample from the contemporary UK population |
| title_sort | extreme inbreeding in a european ancestry sample from the contemporary uk population |
| url | https://doi.org/10.1038/s41467-019-11724-6 |
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