Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases
Serum magnesium is associated with osteoporosis and cardiometabolic diseases, but their causal associations remain elusive. We used the two-sample Mendelian randomization (MR) study to explore the causal roles of serum magnesium on osteoporosis and cardiometabolic diseases by using the aggregated ge...
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| Format: | Article |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.738000/full |
| _version_ | 1819038263333093376 |
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| author | Bin He Liang Xia Jinqiu Zhao Lifeng Yin Muzi Zhang Zhengxue Quan Yunsheng Ou Wei Huang |
| author_facet | Bin He Liang Xia Jinqiu Zhao Lifeng Yin Muzi Zhang Zhengxue Quan Yunsheng Ou Wei Huang |
| author_sort | Bin He |
| collection | DOAJ |
| description | Serum magnesium is associated with osteoporosis and cardiometabolic diseases, but their causal associations remain elusive. We used the two-sample Mendelian randomization (MR) study to explore the causal roles of serum magnesium on osteoporosis and cardiometabolic diseases by using the aggregated genome-wide association studies (GWASs). Six single-nucleotide polymorphisms (SNPs, p < 5 × 10−8) associated with serum magnesium concentrations were all used as instrumental variables. A genetic predisposition to higher serum magnesium concentrations was inversely associated with lower lumbar spine bone mineral density (BMD, beta-estimate: −1.982, 95% CI: −3.328 to −0.635, SE: 0.687, p = 0.004), which was further confirmed by multiple sensitivity analyses. There was limited evidence of associations between serum magnesium and type 2 diabetes, coronary artery disease, heart failure, and atrial fibrillation. This work provided strong evidence that genetically increased serum magnesium concentrations were causally associated with low lumbar spine BMD and suggested that serum magnesium concentrations may be crucial to prevent osteoporosis. |
| first_indexed | 2024-12-21T08:34:32Z |
| format | Article |
| id | doaj.art-c4dee781c67d41b8b29a8a672765733a |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-21T08:34:32Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-c4dee781c67d41b8b29a8a672765733a2022-12-21T19:10:07ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-12-01810.3389/fnut.2021.738000738000Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic DiseasesBin He0Liang Xia1Jinqiu Zhao2Lifeng Yin3Muzi Zhang4Zhengxue Quan5Yunsheng Ou6Wei Huang7Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaSerum magnesium is associated with osteoporosis and cardiometabolic diseases, but their causal associations remain elusive. We used the two-sample Mendelian randomization (MR) study to explore the causal roles of serum magnesium on osteoporosis and cardiometabolic diseases by using the aggregated genome-wide association studies (GWASs). Six single-nucleotide polymorphisms (SNPs, p < 5 × 10−8) associated with serum magnesium concentrations were all used as instrumental variables. A genetic predisposition to higher serum magnesium concentrations was inversely associated with lower lumbar spine bone mineral density (BMD, beta-estimate: −1.982, 95% CI: −3.328 to −0.635, SE: 0.687, p = 0.004), which was further confirmed by multiple sensitivity analyses. There was limited evidence of associations between serum magnesium and type 2 diabetes, coronary artery disease, heart failure, and atrial fibrillation. This work provided strong evidence that genetically increased serum magnesium concentrations were causally associated with low lumbar spine BMD and suggested that serum magnesium concentrations may be crucial to prevent osteoporosis.https://www.frontiersin.org/articles/10.3389/fnut.2021.738000/fullserum magnesiumlumbar spine BMDosteoporosiscardiometabolic diseasesMendelian randomization study |
| spellingShingle | Bin He Liang Xia Jinqiu Zhao Lifeng Yin Muzi Zhang Zhengxue Quan Yunsheng Ou Wei Huang Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases Frontiers in Nutrition serum magnesium lumbar spine BMD osteoporosis cardiometabolic diseases Mendelian randomization study |
| title | Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases |
| title_full | Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases |
| title_fullStr | Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases |
| title_full_unstemmed | Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases |
| title_short | Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases |
| title_sort | causal effect of serum magnesium on osteoporosis and cardiometabolic diseases |
| topic | serum magnesium lumbar spine BMD osteoporosis cardiometabolic diseases Mendelian randomization study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.738000/full |
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