Clinical and morphological characteristics of wound healing in diabetic foot syndrome
Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn) Materials and Methods. Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1—healed ulcers (30 samples), group 2&am...
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| Format: | Article |
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Endocrinology Research Centre
2017-06-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/8190 |
| _version_ | 1797255170112880640 |
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| author | Elena Yur'evna Komelyagina Eugenia Alexandrovna Kogan Mikhail Borisovich Antsiferov |
| author_facet | Elena Yur'evna Komelyagina Eugenia Alexandrovna Kogan Mikhail Borisovich Antsiferov |
| author_sort | Elena Yur'evna Komelyagina |
| collection | DOAJ |
| description | Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn) Materials and Methods. Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1—healed ulcers (30 samples), group 2—unhealed ulcers (13 samples). The following characteristics were analysed: age, sex, glycated haemoglobin (HbA1c), ulcer duration, time of admission to the specialised clinic, severity of neuropathy, presence of late complications, plantar localisation, percentage of necrotic tissue, granulation and fibrotic tissue and, Ki-67expression. Results. Patients were similar in age, HbA1c, severity of late complications and plantar localisation. There was a significant difference in the time of admission to the specialised clinic [50 vs 132 days, p = 0.03], percentage of granulation [61 ± 25 vs 32 ± 21 %, р = 0.001] and fibrotic tissue [24 ± 24 vs 49 ± 22 %, р = 0.002], the granulation/fibrosis coefficient [7.5 ± 8.1 vs 1.9 ± 4.6 (%), р = 0,02] and expression of Ki-67 [15 ± 8 vs ± 21 (%), р = 0.001] between groups. A multidimensional model revealed granulation tissue as the main parameter influencing healing. The probability of healing was 1.0 if the percentage of granulation tissue was <50%. If the percentage of granulation tissue was <50%, the prognosis of healing was determined by the expression of Ki-67. When Ki-67 levels were >7%, the probability of healing was 0.75. For Ki-67 levels ≤7%, the probability of healing was 0.17 and the probability of not healing was 0.83. Conclusion. The time at which a patient was admitted to the specialised clinic and the percentage of granulation tissue were key factors affecting the prognosis of wound healing in DFUn. |
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| id | doaj.art-c4deec3af8f14a789bdbd57f1891fc75 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:01:35Z |
| publishDate | 2017-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-c4deec3af8f14a789bdbd57f1891fc752024-03-20T11:48:01ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782017-06-0120213514110.14341/77047788Clinical and morphological characteristics of wound healing in diabetic foot syndromeElena Yur'evna Komelyagina0Eugenia Alexandrovna Kogan1Mikhail Borisovich Antsiferov2<p>State Moscow Endocrine Dispensary</p><p>I.M.Sechenov First Moscow State Medical University</p><p>State Moscow Endocrine Dispensary</p>Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn) Materials and Methods. Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1—healed ulcers (30 samples), group 2—unhealed ulcers (13 samples). The following characteristics were analysed: age, sex, glycated haemoglobin (HbA1c), ulcer duration, time of admission to the specialised clinic, severity of neuropathy, presence of late complications, plantar localisation, percentage of necrotic tissue, granulation and fibrotic tissue and, Ki-67expression. Results. Patients were similar in age, HbA1c, severity of late complications and plantar localisation. There was a significant difference in the time of admission to the specialised clinic [50 vs 132 days, p = 0.03], percentage of granulation [61 ± 25 vs 32 ± 21 %, р = 0.001] and fibrotic tissue [24 ± 24 vs 49 ± 22 %, р = 0.002], the granulation/fibrosis coefficient [7.5 ± 8.1 vs 1.9 ± 4.6 (%), р = 0,02] and expression of Ki-67 [15 ± 8 vs ± 21 (%), р = 0.001] between groups. A multidimensional model revealed granulation tissue as the main parameter influencing healing. The probability of healing was 1.0 if the percentage of granulation tissue was <50%. If the percentage of granulation tissue was <50%, the prognosis of healing was determined by the expression of Ki-67. When Ki-67 levels were >7%, the probability of healing was 0.75. For Ki-67 levels ≤7%, the probability of healing was 0.17 and the probability of not healing was 0.83. Conclusion. The time at which a patient was admitted to the specialised clinic and the percentage of granulation tissue were key factors affecting the prognosis of wound healing in DFUn.https://www.dia-endojournals.ru/jour/article/view/8190diabetes mellitusdiabetic foot syndrompredictors of neuropathic diabetic foot ulcers healinggranulation tissuefibrosiski67 |
| spellingShingle | Elena Yur'evna Komelyagina Eugenia Alexandrovna Kogan Mikhail Borisovich Antsiferov Clinical and morphological characteristics of wound healing in diabetic foot syndrome Сахарный диабет diabetes mellitus diabetic foot syndrom predictors of neuropathic diabetic foot ulcers healing granulation tissue fibrosis ki67 |
| title | Clinical and morphological characteristics of wound healing in diabetic foot syndrome |
| title_full | Clinical and morphological characteristics of wound healing in diabetic foot syndrome |
| title_fullStr | Clinical and morphological characteristics of wound healing in diabetic foot syndrome |
| title_full_unstemmed | Clinical and morphological characteristics of wound healing in diabetic foot syndrome |
| title_short | Clinical and morphological characteristics of wound healing in diabetic foot syndrome |
| title_sort | clinical and morphological characteristics of wound healing in diabetic foot syndrome |
| topic | diabetes mellitus diabetic foot syndrom predictors of neuropathic diabetic foot ulcers healing granulation tissue fibrosis ki67 |
| url | https://www.dia-endojournals.ru/jour/article/view/8190 |
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