Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier
One drawback of traditional forms of medical ocular dosage is drug dilution by tear; moreover, drugs are rapidly drained away from pre-corneal cavity by tear flow and lacrimo-nasal drainage. Prolonging contact time with different strategies and mucoadhesive vehicles will help to continuously deliver...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-04-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | http://www.mdpi.com/2218-0532/86/2/16 |
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| author | Behzad Sharif Makhmal Zadeh Hassan Niro Fakher Rahim Golbarg Esfahani |
| author_facet | Behzad Sharif Makhmal Zadeh Hassan Niro Fakher Rahim Golbarg Esfahani |
| author_sort | Behzad Sharif Makhmal Zadeh |
| collection | DOAJ |
| description | One drawback of traditional forms of medical ocular dosage is drug dilution by tear; moreover, drugs are rapidly drained away from pre-corneal cavity by tear flow and lacrimo-nasal drainage. Prolonging contact time with different strategies and mucoadhesive vehicles will help to continuously deliver drugs to the eyes. For this study, we prepared and evaluated the effects of a nanostructure lipid carrier (NLC) on propranolol hydrochloride as a hydrophilic drug model for rabbit corneal permeation. Propranolol hydrochloride NLC was prepared using cold homogenization. The lipid was melted, then the drug and surfactant were dispersed and stirred into the melted lipid. This fused lipid phase was scattered in aqueous solution containing the cosurfactant at 4 °C and then homogenized. We evaluated particle size, drug loading, drug release, and NLC permeability through rabbit cornea as well as the formula’s effect on the cornea. Our results show that drug loading efficiency depended on the surfactant/lipid ratio (S/L) and the percentages of liquid lipid and Transcutol (Gattefosse, Saint-Priest, France) (as solubilizer). Drug release data were evaluated with the Higuchi model and a significant correlation was shown between the S/L ratio and the amount of drug released after 4 and 48 h. NLC formulations improved propranolol hydrochloride permeation. We conclude that the effect of the NLC formulations was due to mucoadhesive and film forming properties. |
| first_indexed | 2024-12-10T07:20:48Z |
| format | Article |
| id | doaj.art-c4e06bf0459240ac95b95b71d1bcb3e3 |
| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-12-10T07:20:48Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-c4e06bf0459240ac95b95b71d1bcb3e32022-12-22T01:57:49ZengMDPI AGScientia Pharmaceutica2218-05322018-04-018621610.3390/scipharm86020016scipharm86020016Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid CarrierBehzad Sharif Makhmal Zadeh0Hassan Niro1Fakher Rahim2Golbarg Esfahani3Nanotechnology Research Center, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, 6135715794 Ahvaz, IranDepartment of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, 6135715794 Ahvaz, IranResearch Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Ciences, 6135715794 Ahvaz, IranDepartment of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, 6135715794 Ahvaz, IranOne drawback of traditional forms of medical ocular dosage is drug dilution by tear; moreover, drugs are rapidly drained away from pre-corneal cavity by tear flow and lacrimo-nasal drainage. Prolonging contact time with different strategies and mucoadhesive vehicles will help to continuously deliver drugs to the eyes. For this study, we prepared and evaluated the effects of a nanostructure lipid carrier (NLC) on propranolol hydrochloride as a hydrophilic drug model for rabbit corneal permeation. Propranolol hydrochloride NLC was prepared using cold homogenization. The lipid was melted, then the drug and surfactant were dispersed and stirred into the melted lipid. This fused lipid phase was scattered in aqueous solution containing the cosurfactant at 4 °C and then homogenized. We evaluated particle size, drug loading, drug release, and NLC permeability through rabbit cornea as well as the formula’s effect on the cornea. Our results show that drug loading efficiency depended on the surfactant/lipid ratio (S/L) and the percentages of liquid lipid and Transcutol (Gattefosse, Saint-Priest, France) (as solubilizer). Drug release data were evaluated with the Higuchi model and a significant correlation was shown between the S/L ratio and the amount of drug released after 4 and 48 h. NLC formulations improved propranolol hydrochloride permeation. We conclude that the effect of the NLC formulations was due to mucoadhesive and film forming properties.http://www.mdpi.com/2218-0532/86/2/16oculardrug deliverypermeabilitypropranolol hydrochloridenanostructured lipid carrier |
| spellingShingle | Behzad Sharif Makhmal Zadeh Hassan Niro Fakher Rahim Golbarg Esfahani Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier Scientia Pharmaceutica ocular drug delivery permeability propranolol hydrochloride nanostructured lipid carrier |
| title | Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier |
| title_full | Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier |
| title_fullStr | Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier |
| title_full_unstemmed | Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier |
| title_short | Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier |
| title_sort | ocular delivery system for propranolol hydrochloride based on nanostructured lipid carrier |
| topic | ocular drug delivery permeability propranolol hydrochloride nanostructured lipid carrier |
| url | http://www.mdpi.com/2218-0532/86/2/16 |
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