Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle
Glyoxylate serves as intermediate in various metabolic pathways, although high concentrations of this metabolite are toxic to the cell. In many organisms glyoxylate is fed into the glyoxylate cycle. Enzymes participating in this metabolism are located on both sides of the peroxisomal membrane. The p...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-08-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00204/full |
| _version_ | 1811256175692349440 |
|---|---|
| author | Markus eKunze Andreas eHartig |
| author_facet | Markus eKunze Andreas eHartig |
| author_sort | Markus eKunze |
| collection | DOAJ |
| description | Glyoxylate serves as intermediate in various metabolic pathways, although high concentrations of this metabolite are toxic to the cell. In many organisms glyoxylate is fed into the glyoxylate cycle. Enzymes participating in this metabolism are located on both sides of the peroxisomal membrane. The permeability of this membrane for small metabolites paves the way for exchange of intermediates between proteins catalyzing consecutive reactions. A model, in which soluble enzymes accumulate in close proximity to both ends of pore-like structures forming a transmembrane metabolon could explain the rapid and targeted exchange of intermediates. The metabolites passing the membrane differ between the three model organisms Saccharomyces cerevisiae, Arabidopsis thaliana and Candida albicans, which reflects the ease of evolutionary adaptation processes whenever specific transporter proteins are not involved. The atypical permeability properties of the peroxisomal membrane together with a flexible structural arrangement ensuring the swift and selective transport across the membrane might represent the molecular basis for the functional versatility of peroxisomes. |
| first_indexed | 2024-04-12T17:36:09Z |
| format | Article |
| id | doaj.art-c4e0bb560174416c8abc96c68307d23f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T17:36:09Z |
| publishDate | 2013-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c4e0bb560174416c8abc96c68307d23f2022-12-22T03:22:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2013-08-01410.3389/fphys.2013.0020460393Permeability of the peroxisomal membrane: lessons from the glyoxylate cycleMarkus eKunze0Andreas eHartig1Center for Brain Research, Medical University of ViennaMax F. Perutz Laboratories, University of ViennaGlyoxylate serves as intermediate in various metabolic pathways, although high concentrations of this metabolite are toxic to the cell. In many organisms glyoxylate is fed into the glyoxylate cycle. Enzymes participating in this metabolism are located on both sides of the peroxisomal membrane. The permeability of this membrane for small metabolites paves the way for exchange of intermediates between proteins catalyzing consecutive reactions. A model, in which soluble enzymes accumulate in close proximity to both ends of pore-like structures forming a transmembrane metabolon could explain the rapid and targeted exchange of intermediates. The metabolites passing the membrane differ between the three model organisms Saccharomyces cerevisiae, Arabidopsis thaliana and Candida albicans, which reflects the ease of evolutionary adaptation processes whenever specific transporter proteins are not involved. The atypical permeability properties of the peroxisomal membrane together with a flexible structural arrangement ensuring the swift and selective transport across the membrane might represent the molecular basis for the functional versatility of peroxisomes.http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00204/fullPeroxisomesphotorespirationMembrane Permeabilityglyoxylate cycleglyoxylatemetabolon |
| spellingShingle | Markus eKunze Andreas eHartig Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle Frontiers in Physiology Peroxisomes photorespiration Membrane Permeability glyoxylate cycle glyoxylate metabolon |
| title | Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle |
| title_full | Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle |
| title_fullStr | Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle |
| title_full_unstemmed | Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle |
| title_short | Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle |
| title_sort | permeability of the peroxisomal membrane lessons from the glyoxylate cycle |
| topic | Peroxisomes photorespiration Membrane Permeability glyoxylate cycle glyoxylate metabolon |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00204/full |
| work_keys_str_mv | AT markusekunze permeabilityoftheperoxisomalmembranelessonsfromtheglyoxylatecycle AT andreasehartig permeabilityoftheperoxisomalmembranelessonsfromtheglyoxylatecycle |