Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra
Understanding how mechanics complement bio-signaling in defining patterns during morphogenesis is an outstanding challenge. Here, we utilize the multicellular polyp Hydra to investigate the role of the actomyosin cytoskeleton in morphogenesis. We find that the supra-cellular actin fiber organization...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717300736 |
| _version_ | 1818534607241347072 |
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| author | Anton Livshits Lital Shani-Zerbib Yonit Maroudas-Sacks Erez Braun Kinneret Keren |
| author_facet | Anton Livshits Lital Shani-Zerbib Yonit Maroudas-Sacks Erez Braun Kinneret Keren |
| author_sort | Anton Livshits |
| collection | DOAJ |
| description | Understanding how mechanics complement bio-signaling in defining patterns during morphogenesis is an outstanding challenge. Here, we utilize the multicellular polyp Hydra to investigate the role of the actomyosin cytoskeleton in morphogenesis. We find that the supra-cellular actin fiber organization is inherited from the parent Hydra and determines the body axis in regenerating tissue segments. This form of structural inheritance is non-trivial because of the tissue folding and dynamic actin reorganization involved. We further show that the emergence of multiple body axes can be traced to discrepancies in actin fiber alignment at early stages of the regeneration process. Mechanical constraints induced by anchoring regenerating Hydra on stiff wires suppressed the emergence of multiple body axes, highlighting the importance of mechanical feedbacks in defining and stabilizing the body axis. Together, these results constitute an important step toward the development of an integrated view of morphogenesis that incorporates mechanics. |
| first_indexed | 2024-12-11T18:13:46Z |
| format | Article |
| id | doaj.art-c4e162e6b8f246548a7cb4cbdf116e7f |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T18:13:46Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c4e162e6b8f246548a7cb4cbdf116e7f2022-12-22T00:55:29ZengElsevierCell Reports2211-12472017-02-011861410142110.1016/j.celrep.2017.01.036Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating HydraAnton Livshits0Lital Shani-Zerbib1Yonit Maroudas-Sacks2Erez Braun3Kinneret Keren4Department of Physics, Technion – Israel Institute of Technology, Haifa 32000, IsraelDepartment of Physics, Technion – Israel Institute of Technology, Haifa 32000, IsraelDepartment of Physics, Technion – Israel Institute of Technology, Haifa 32000, IsraelDepartment of Physics, Technion – Israel Institute of Technology, Haifa 32000, IsraelDepartment of Physics, Technion – Israel Institute of Technology, Haifa 32000, IsraelUnderstanding how mechanics complement bio-signaling in defining patterns during morphogenesis is an outstanding challenge. Here, we utilize the multicellular polyp Hydra to investigate the role of the actomyosin cytoskeleton in morphogenesis. We find that the supra-cellular actin fiber organization is inherited from the parent Hydra and determines the body axis in regenerating tissue segments. This form of structural inheritance is non-trivial because of the tissue folding and dynamic actin reorganization involved. We further show that the emergence of multiple body axes can be traced to discrepancies in actin fiber alignment at early stages of the regeneration process. Mechanical constraints induced by anchoring regenerating Hydra on stiff wires suppressed the emergence of multiple body axes, highlighting the importance of mechanical feedbacks in defining and stabilizing the body axis. Together, these results constitute an important step toward the development of an integrated view of morphogenesis that incorporates mechanics.http://www.sciencedirect.com/science/article/pii/S2211124717300736morphogenesishydrastructural inheritancemechanical self-organizationmechanical feedbacksactin cytoskeleton |
| spellingShingle | Anton Livshits Lital Shani-Zerbib Yonit Maroudas-Sacks Erez Braun Kinneret Keren Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra Cell Reports morphogenesis hydra structural inheritance mechanical self-organization mechanical feedbacks actin cytoskeleton |
| title | Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra |
| title_full | Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra |
| title_fullStr | Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra |
| title_full_unstemmed | Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra |
| title_short | Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra |
| title_sort | structural inheritance of the actin cytoskeletal organization determines the body axis in regenerating hydra |
| topic | morphogenesis hydra structural inheritance mechanical self-organization mechanical feedbacks actin cytoskeleton |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717300736 |
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