G2019S LRRK2 Increases Stress Susceptibility Through Inhibition of DAF-16 Nuclear Translocation in a 14-3-3 Associated-Manner in Caenorhabditis elegans

G2019S LRRK2 Increases Stress Susceptibility Through Inhibition of DAF-16 Nuclear Translocation in a 14-3-3 Associated-Manner in Caenorhabditis elegans

Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson’s disease (PD). Oxidative stress plays a key role in the pathogenesis of PD. Mutations in LRRK2 have been shown to increase susceptibility to oxidative stress. To explore mechanisms underlying susceptibility to...

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Bibliographic Details
Main Authors: Simei Long, Wenyuan Guo, Sophie Hu, Fengjuan Su, Yixuan Zeng, Jinsheng Zeng, Eng-King Tan, Christopher A. Ross, Zhong Pei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
G2019S LRRK2
stress
14-3-3
daf-16
Caenorhabditis elegans
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00782/full

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