The Swine IFN System in Viral Infections: Major Advances and Translational Prospects
Interferons (IFNs) are a family of cytokines that play a pivotal role in orchestrating the innate immune response during viral infections, thus representing the first line of defense in the host. After binding to their respective receptors, they are able to elicit a plethora of biological activities...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/2/175 |
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| author | Elisabetta Razzuoli Federico Armando Livia De Paolis Malgorzata Ciurkiewicz Massimo Amadori |
| author_facet | Elisabetta Razzuoli Federico Armando Livia De Paolis Malgorzata Ciurkiewicz Massimo Amadori |
| author_sort | Elisabetta Razzuoli |
| collection | DOAJ |
| description | Interferons (IFNs) are a family of cytokines that play a pivotal role in orchestrating the innate immune response during viral infections, thus representing the first line of defense in the host. After binding to their respective receptors, they are able to elicit a plethora of biological activities, by initiating signaling cascades which lead to the transcription of genes involved in antiviral, anti-inflammatory, immunomodulatory and antitumoral effector mechanisms. In hindsight, it is not surprising that viruses have evolved multiple IFN escape strategies toward efficient replication in the host. Hence, in order to achieve insight into preventive and treatment strategies, it is essential to explore the mechanisms underlying the IFN response to viral infections and the constraints thereof. Accordingly, this review is focused on three RNA and three DNA viruses of major importance in the swine farming sector, aiming to provide essential data as to how the IFN system modulates the antiviral immune response, and is affected by diverse, virus-driven, immune escape mechanisms. |
| first_indexed | 2024-03-09T21:17:16Z |
| format | Article |
| id | doaj.art-c4e8ca267f9e45788c826ba634368742 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T21:17:16Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-c4e8ca267f9e45788c826ba6343687422023-11-23T21:31:32ZengMDPI AGPathogens2076-08172022-01-0111217510.3390/pathogens11020175The Swine IFN System in Viral Infections: Major Advances and Translational ProspectsElisabetta Razzuoli0Federico Armando1Livia De Paolis2Malgorzata Ciurkiewicz3Massimo Amadori4National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D’Aosta, Piazza Borgo Pila 39/24, 16129 Genoa, ItalyDepartment of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, GermanyNational Reference Center of Veterinary and Comparative Oncology (CEROVEC), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D’Aosta, Piazza Borgo Pila 39/24, 16129 Genoa, ItalyDepartment of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, GermanyNational Network of Veterinary Immunology (RNIV), Via Istria 3, 25125 Brescia, ItalyInterferons (IFNs) are a family of cytokines that play a pivotal role in orchestrating the innate immune response during viral infections, thus representing the first line of defense in the host. After binding to their respective receptors, they are able to elicit a plethora of biological activities, by initiating signaling cascades which lead to the transcription of genes involved in antiviral, anti-inflammatory, immunomodulatory and antitumoral effector mechanisms. In hindsight, it is not surprising that viruses have evolved multiple IFN escape strategies toward efficient replication in the host. Hence, in order to achieve insight into preventive and treatment strategies, it is essential to explore the mechanisms underlying the IFN response to viral infections and the constraints thereof. Accordingly, this review is focused on three RNA and three DNA viruses of major importance in the swine farming sector, aiming to provide essential data as to how the IFN system modulates the antiviral immune response, and is affected by diverse, virus-driven, immune escape mechanisms.https://www.mdpi.com/2076-0817/11/2/175piginterferonsviral infections |
| spellingShingle | Elisabetta Razzuoli Federico Armando Livia De Paolis Malgorzata Ciurkiewicz Massimo Amadori The Swine IFN System in Viral Infections: Major Advances and Translational Prospects Pathogens pig interferons viral infections |
| title | The Swine IFN System in Viral Infections: Major Advances and Translational Prospects |
| title_full | The Swine IFN System in Viral Infections: Major Advances and Translational Prospects |
| title_fullStr | The Swine IFN System in Viral Infections: Major Advances and Translational Prospects |
| title_full_unstemmed | The Swine IFN System in Viral Infections: Major Advances and Translational Prospects |
| title_short | The Swine IFN System in Viral Infections: Major Advances and Translational Prospects |
| title_sort | swine ifn system in viral infections major advances and translational prospects |
| topic | pig interferons viral infections |
| url | https://www.mdpi.com/2076-0817/11/2/175 |
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