Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting
Background: The cardiovascular (CV) risk of patients with Type 2 diabetes (T2D) of Indo-Asian descent has never been objectively assessed, although it is documented that they have a higher prevalence of CV disease (CVD). Aims: To identify groups of Indian patients with asymptomatic T2D who are at hi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Indian Heart Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483220300523 |
| _version_ | 1819000401866784768 |
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| author | Samit Ghosal Binayak Sinha Jignesh Ved Mansij Biswas |
| author_facet | Samit Ghosal Binayak Sinha Jignesh Ved Mansij Biswas |
| author_sort | Samit Ghosal |
| collection | DOAJ |
| description | Background: The cardiovascular (CV) risk of patients with Type 2 diabetes (T2D) of Indo-Asian descent has never been objectively assessed, although it is documented that they have a higher prevalence of CV disease (CVD). Aims: To identify groups of Indian patients with asymptomatic T2D who are at high risk of CVD as per the QRISK calculator. Method: After an adequate power calculation, a nation-wide study of patients with asymptomatic T2D was conducted. The QRISK3 scores of these patients were used to derive a 10-year risk of CV events. High CVD risk was defined as ≥20% risk of CV event in 10 years. Results: For a total of 1538 patients across 154 outpatient departments, the QRISK3 scores were collated. Median 10-year CVD risk was 22.2%. Mean 10-year CVD risk was 28.4% (standard deviation 22.1%), representing a 5.7-fold increase vs. controls (i.e., matched healthy adults). Absolute CVD risk increased linearly with age. Over 50% of T2D males aged above 45 years had a high (>20%) CVD risk. Women aged more than 55 years had a high risk of CVD. More than 50% of patients with a T2D duration of more than 5 years had a high risk of CVD as per the QRISK3 calculator. |
| first_indexed | 2024-12-20T22:32:44Z |
| format | Article |
| id | doaj.art-c4e917e856e44fa98bae929e7d2a29d6 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-12-20T22:32:44Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-c4e917e856e44fa98bae929e7d2a29d62022-12-21T19:24:42ZengElsevierIndian Heart Journal0019-48322020-03-01722119122Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient settingSamit Ghosal0Binayak Sinha1Jignesh Ved2Mansij Biswas3Nightingale Hospital, Kolkata, India; Corresponding author.AMRI Hospitals, Kolkata, IndiaBoehringer Ingelheim, Mumbai, IndiaBoehringer Ingelheim, Mumbai, IndiaBackground: The cardiovascular (CV) risk of patients with Type 2 diabetes (T2D) of Indo-Asian descent has never been objectively assessed, although it is documented that they have a higher prevalence of CV disease (CVD). Aims: To identify groups of Indian patients with asymptomatic T2D who are at high risk of CVD as per the QRISK calculator. Method: After an adequate power calculation, a nation-wide study of patients with asymptomatic T2D was conducted. The QRISK3 scores of these patients were used to derive a 10-year risk of CV events. High CVD risk was defined as ≥20% risk of CV event in 10 years. Results: For a total of 1538 patients across 154 outpatient departments, the QRISK3 scores were collated. Median 10-year CVD risk was 22.2%. Mean 10-year CVD risk was 28.4% (standard deviation 22.1%), representing a 5.7-fold increase vs. controls (i.e., matched healthy adults). Absolute CVD risk increased linearly with age. Over 50% of T2D males aged above 45 years had a high (>20%) CVD risk. Women aged more than 55 years had a high risk of CVD. More than 50% of patients with a T2D duration of more than 5 years had a high risk of CVD as per the QRISK3 calculator.http://www.sciencedirect.com/science/article/pii/S0019483220300523Type 2 diabetesCV riskQRISK3Indian patientsAsymptomatic |
| spellingShingle | Samit Ghosal Binayak Sinha Jignesh Ved Mansij Biswas Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting Indian Heart Journal Type 2 diabetes CV risk QRISK3 Indian patients Asymptomatic |
| title | Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting |
| title_full | Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting |
| title_fullStr | Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting |
| title_full_unstemmed | Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting |
| title_short | Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting |
| title_sort | quantitative measure of asymptomatic cardiovascular disease risk in type 2 diabetes evidence from indian outpatient setting |
| topic | Type 2 diabetes CV risk QRISK3 Indian patients Asymptomatic |
| url | http://www.sciencedirect.com/science/article/pii/S0019483220300523 |
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