Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds
Fluorine-containing functional groups are important motifs influencing physical and biological properties of organic compounds. Visible-light photoredox catalysis as a powerful strategy for the activation of small molecules contributed significantly to the rapid progress of new synthetic procedures...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Catalysts |
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| Online Access: | https://www.mdpi.com/2073-4344/13/1/94 |
| _version_ | 1797444667350974464 |
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| author | Tomasz Kliś |
| author_facet | Tomasz Kliś |
| author_sort | Tomasz Kliś |
| collection | DOAJ |
| description | Fluorine-containing functional groups are important motifs influencing physical and biological properties of organic compounds. Visible-light photoredox catalysis as a powerful strategy for the activation of small molecules contributed significantly to the rapid progress of new synthetic procedures allowing introduction of fluorine atoms into organic substrates. In this review, we highlight the distinct strategies for transition metal- and organic-photocatalytic fluorination of arenes and heteroarenes by a broad range of fluorinating compounds. The presented procedures are divided into two groups. The first group involves the reactions enabling a direct attachment of CF<sub>3</sub>-, C<sub>n</sub>F<sub>m</sub>-, F-, CF<sub>3</sub>O-, CF<sub>3</sub>S-, and SO<sub>2</sub>F- substituents to various aromatic compounds. The second group presents the tandem reactions where the formation of the aromatic system occurs after installation of the fluorine-containing group on the non-aromatic fragment of the molecule. |
| first_indexed | 2024-03-09T13:14:53Z |
| format | Article |
| id | doaj.art-c4e9904d08284d84b369d318d43966ef |
| institution | Directory Open Access Journal |
| issn | 2073-4344 |
| language | English |
| last_indexed | 2024-03-09T13:14:53Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Catalysts |
| spelling | doaj.art-c4e9904d08284d84b369d318d43966ef2023-11-30T21:37:09ZengMDPI AGCatalysts2073-43442023-01-011319410.3390/catal13010094Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic CompoundsTomasz Kliś0Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFluorine-containing functional groups are important motifs influencing physical and biological properties of organic compounds. Visible-light photoredox catalysis as a powerful strategy for the activation of small molecules contributed significantly to the rapid progress of new synthetic procedures allowing introduction of fluorine atoms into organic substrates. In this review, we highlight the distinct strategies for transition metal- and organic-photocatalytic fluorination of arenes and heteroarenes by a broad range of fluorinating compounds. The presented procedures are divided into two groups. The first group involves the reactions enabling a direct attachment of CF<sub>3</sub>-, C<sub>n</sub>F<sub>m</sub>-, F-, CF<sub>3</sub>O-, CF<sub>3</sub>S-, and SO<sub>2</sub>F- substituents to various aromatic compounds. The second group presents the tandem reactions where the formation of the aromatic system occurs after installation of the fluorine-containing group on the non-aromatic fragment of the molecule.https://www.mdpi.com/2073-4344/13/1/94photocatalysisfluorinationarenesheteroarenestandem reactions |
| spellingShingle | Tomasz Kliś Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds Catalysts photocatalysis fluorination arenes heteroarenes tandem reactions |
| title | Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds |
| title_full | Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds |
| title_fullStr | Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds |
| title_full_unstemmed | Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds |
| title_short | Visible-Light Photoredox Catalysis for the Synthesis of Fluorinated Aromatic Compounds |
| title_sort | visible light photoredox catalysis for the synthesis of fluorinated aromatic compounds |
| topic | photocatalysis fluorination arenes heteroarenes tandem reactions |
| url | https://www.mdpi.com/2073-4344/13/1/94 |
| work_keys_str_mv | AT tomaszklis visiblelightphotoredoxcatalysisforthesynthesisoffluorinatedaromaticcompounds |