Life course plasma metabolomic signatures of genetic liability to Alzheimer’s disease

Life course plasma metabolomic signatures of genetic liability to Alzheimer’s disease

Abstract Mechanisms through which most known Alzheimer’s disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD genetic liability on non-lipid metabolites remain unknown, and the earliest ages a...

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Bibliographic Details
Main Authors: Hannah Compton, Madeleine L. Smith, Caroline Bull, Roxanna Korologou-Linden, Yoav Ben-Shlomo, Joshua A. Bell, Dylan M. Williams, Emma L. Anderson
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
APOE
Polygenic risk score
Mendelian randomization
Metabolism
NMR
Online Access:https://doi.org/10.1038/s41598-024-54569-w

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