Life course plasma metabolomic signatures of genetic liability to Alzheimer’s disease

Life course plasma metabolomic signatures of genetic liability to Alzheimer’s disease

Abstract Mechanisms through which most known Alzheimer’s disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD genetic liability on non-lipid metabolites remain unknown, and the earliest ages a...

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Dettagli Bibliografici
Autori principali:	Hannah Compton, Madeleine L. Smith, Caroline Bull, Roxanna Korologou-Linden, Yoav Ben-Shlomo, Joshua A. Bell, Dylan M. Williams, Emma L. Anderson
Natura:	Articolo
Lingua:	English
Pubblicazione:	Nature Portfolio 2024-02-01
Serie:	Scientific Reports
Soggetti:	Alzheimer’s disease APOE Polygenic risk score Mendelian randomization Metabolism NMR
Accesso online:	https://doi.org/10.1038/s41598-024-54569-w

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