Life course plasma metabolomic signatures of genetic liability to Alzheimer’s disease

Life course plasma metabolomic signatures of genetic liability to Alzheimer’s disease

Abstract Mechanisms through which most known Alzheimer’s disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD genetic liability on non-lipid metabolites remain unknown, and the earliest ages a...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Hannah Compton, Madeleine L. Smith, Caroline Bull, Roxanna Korologou-Linden, Yoav Ben-Shlomo, Joshua A. Bell, Dylan M. Williams, Emma L. Anderson
Format:	Artykuł
Język:	English
Wydane:	Nature Portfolio 2024-02-01
Seria:	Scientific Reports
Hasła przedmiotowe:	Alzheimer’s disease APOE Polygenic risk score Mendelian randomization Metabolism NMR
Dostęp online:	https://doi.org/10.1038/s41598-024-54569-w

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