Rapid determination of quaternary protein structures in complex biological samples
Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07986-1 |
| _version_ | 1818977907828064256 |
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| author | Simon Hauri Hamed Khakzad Lotta Happonen Johan Teleman Johan Malmström Lars Malmström |
| author_facet | Simon Hauri Hamed Khakzad Lotta Happonen Johan Teleman Johan Malmström Lars Malmström |
| author_sort | Simon Hauri |
| collection | DOAJ |
| description | Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma and bacteria. |
| first_indexed | 2024-12-20T16:35:12Z |
| format | Article |
| id | doaj.art-c4ea55d53e294d409643497524b1ae3d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:35:12Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c4ea55d53e294d409643497524b1ae3d2022-12-21T19:33:10ZengNature PortfolioNature Communications2041-17232019-01-0110111010.1038/s41467-018-07986-1Rapid determination of quaternary protein structures in complex biological samplesSimon Hauri0Hamed Khakzad1Lotta Happonen2Johan Teleman3Johan Malmström4Lars Malmström5Division of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund UniversityS3IT, University of ZurichDivision of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund UniversityDivision of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund UniversityDivision of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund UniversityDivision of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund UniversityProtein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma and bacteria.https://doi.org/10.1038/s41467-018-07986-1 |
| spellingShingle | Simon Hauri Hamed Khakzad Lotta Happonen Johan Teleman Johan Malmström Lars Malmström Rapid determination of quaternary protein structures in complex biological samples Nature Communications |
| title | Rapid determination of quaternary protein structures in complex biological samples |
| title_full | Rapid determination of quaternary protein structures in complex biological samples |
| title_fullStr | Rapid determination of quaternary protein structures in complex biological samples |
| title_full_unstemmed | Rapid determination of quaternary protein structures in complex biological samples |
| title_short | Rapid determination of quaternary protein structures in complex biological samples |
| title_sort | rapid determination of quaternary protein structures in complex biological samples |
| url | https://doi.org/10.1038/s41467-018-07986-1 |
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