Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology Studies
Twenty-eight days subacute toxicity studies performed in rats using sclerotial powder of Lignosus cameronensis cultivar was conducted to assess its safety for consumption prior to other scientific investigations on its medicinal benefits, nutraceutical or pharmaceutical application of the mushroom....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00594/full |
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| author | Sook-Shien Lee Nget-Hong Tan Jayalakshmi Pailoor Shin-Yee Fung |
| author_facet | Sook-Shien Lee Nget-Hong Tan Jayalakshmi Pailoor Shin-Yee Fung |
| author_sort | Sook-Shien Lee |
| collection | DOAJ |
| description | Twenty-eight days subacute toxicity studies performed in rats using sclerotial powder of Lignosus cameronensis cultivar was conducted to assess its safety for consumption prior to other scientific investigations on its medicinal benefits, nutraceutical or pharmaceutical application of the mushroom. The study was conducted at 250, 500, and 1000 mg/kg sclerotial powder of L. cameronensis cultivar (n = 5 for each respective dose, on both male and female groups) while control groups received only distilled water. At the end of the study (29th day), the animals were sacrificed followed by blood and organs collection for analysis. Subacute toxicity studies done shows that sclerotial powder of L. cameronensis cultivar at 250, 500, and 1000 mg/kg did not induce treatment related changes on behavioral patterns, gross physical appearance, growth pattern, body weight gain, values of hematological and clinical biochemical panels as well as histopathological findings on kidney, spleen, heart, lung and liver of the experimental rats. The no-observed-adverse-effect level dose for sclerotial powder of L. cameronensis cultivar in 28-days sub-acute toxicity study is determined to be 1000 mg/kg. |
| first_indexed | 2024-12-23T03:24:22Z |
| format | Article |
| id | doaj.art-c4eb830c757144d9984297a0161686f2 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-23T03:24:22Z |
| publishDate | 2017-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c4eb830c757144d9984297a0161686f22022-12-21T18:01:54ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122017-09-01810.3389/fphar.2017.00594272664Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology StudiesSook-Shien Lee0Nget-Hong Tan1Jayalakshmi Pailoor2Shin-Yee Fung3Department of Molecular Medicine, Faculty of Medicine, University of MalayaKuala Lumpur, MalaysiaDepartment of Molecular Medicine, Faculty of Medicine, University of MalayaKuala Lumpur, MalaysiaDepartment of Pathology, Faculty of Medicine, University of MalayaKuala Lumpur, MalaysiaDepartment of Molecular Medicine, Faculty of Medicine, University of MalayaKuala Lumpur, MalaysiaTwenty-eight days subacute toxicity studies performed in rats using sclerotial powder of Lignosus cameronensis cultivar was conducted to assess its safety for consumption prior to other scientific investigations on its medicinal benefits, nutraceutical or pharmaceutical application of the mushroom. The study was conducted at 250, 500, and 1000 mg/kg sclerotial powder of L. cameronensis cultivar (n = 5 for each respective dose, on both male and female groups) while control groups received only distilled water. At the end of the study (29th day), the animals were sacrificed followed by blood and organs collection for analysis. Subacute toxicity studies done shows that sclerotial powder of L. cameronensis cultivar at 250, 500, and 1000 mg/kg did not induce treatment related changes on behavioral patterns, gross physical appearance, growth pattern, body weight gain, values of hematological and clinical biochemical panels as well as histopathological findings on kidney, spleen, heart, lung and liver of the experimental rats. The no-observed-adverse-effect level dose for sclerotial powder of L. cameronensis cultivar in 28-days sub-acute toxicity study is determined to be 1000 mg/kg.http://journal.frontiersin.org/article/10.3389/fphar.2017.00594/fullLignosus cameronensissclerotiumtoxicityhematologicalhistopathological |
| spellingShingle | Sook-Shien Lee Nget-Hong Tan Jayalakshmi Pailoor Shin-Yee Fung Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology Studies Frontiers in Pharmacology Lignosus cameronensis sclerotium toxicity hematological histopathological |
| title | Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology Studies |
| title_full | Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology Studies |
| title_fullStr | Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology Studies |
| title_full_unstemmed | Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology Studies |
| title_short | Safety Evaluation of Sclerotium from a Medicinal Mushroom, Lignosus cameronensis (Cultivar): Preclinical Toxicology Studies |
| title_sort | safety evaluation of sclerotium from a medicinal mushroom lignosus cameronensis cultivar preclinical toxicology studies |
| topic | Lignosus cameronensis sclerotium toxicity hematological histopathological |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00594/full |
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