Hepcidin deficiency causes bone loss through interfering with the canonical Wnt/β-catenin pathway via Forkhead box O3a

Hepcidin deficiency causes bone loss through interfering with the canonical Wnt/β-catenin pathway via Forkhead box O3a

Objective: Hepcidin deficiency is known to cause body iron accumulation and bone microarchitecture defects, but the exact underlying mechanisms of hepcidin deficiency-induced bone loss remain unclear. Our objective was to understand the molecular mechanism of hepcidin deficiency-induced bone loss. M...

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Bibliographic Details
Main Authors: Guangfei Li, Hui Zhang, Jiadong Wu, Aifei Wang, Fan Yang, Bin Chen, Yan Gao, Xiaowei Ma, Youjia Xu
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Forkhead box O3a
Hepcidin
Osteoblasts
Osteoclasts
Osteoporosis
Wnt/β-catenin pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X20300425

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