Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues.
The relationship of cannabis-use disorder and trauma exposure at the level of the brain is not well-understood. Cue-reactivity paradigms have largely focused on characterizing aberrant subcortical function by averaging across the entire task. However, changes across the task, including a non-habitua...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Drug and Alcohol Dependence Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772724622000737 |
| _version_ | 1797980449708965888 |
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| author | Paul S. Regier Michael J. Gawrysiak Kanchana Jagannathan Anna Rose Childress Teresa R. Franklin Reagan R. Wetherill |
| author_facet | Paul S. Regier Michael J. Gawrysiak Kanchana Jagannathan Anna Rose Childress Teresa R. Franklin Reagan R. Wetherill |
| author_sort | Paul S. Regier |
| collection | DOAJ |
| description | The relationship of cannabis-use disorder and trauma exposure at the level of the brain is not well-understood. Cue-reactivity paradigms have largely focused on characterizing aberrant subcortical function by averaging across the entire task. However, changes across the task, including a non-habituating amygdala response (NHAR), may be a useful biomarker for relapse vulnerability and other pathology. This secondary analysis utilized existing fMRI data from a CUD population with (TR-Y, n = 18) or without trauma (TR-N, n = 15). Amygdala reactivity to novel and repeated aversive cues was examined between TR-Y vs. TR-N groups, using a repeated measures ANOVA. Analysis revealed a significant interaction between TR-Y vs. TR-N and amygdala response to novel vs. repeated cues in the amygdala (right: F (1,31) = 5.31, p = 0.028; left: F (1,31) = 7.42, p = 0.011). In the TR-Y group, a NHAR was evident, while the TR-N group exhibited amygdala habituation, resulting in a significant difference between groups of amygdala reactivity to repeated cues (right: p = 0.002; left: p < 0.001). The NHAR in the TR-Y (but not TR-N) group was significantly correlated with higher cannabis craving scores, yielding a significant group difference (z = 2.1, p = 0.018). Results suggest trauma interacts with the brain's sensitivity to aversive cues, offering a neural explanation for the relationship between trauma and CUD vulnerability. These findings suggest the importance of considering the temporal dynamics of cue reactivity and trauma history in future studies and treatment planning, as this distinction may help decrease relapse vulnerability. |
| first_indexed | 2024-04-11T05:54:43Z |
| format | Article |
| id | doaj.art-c4ece3b07ddd429e9837d324c954c068 |
| institution | Directory Open Access Journal |
| issn | 2772-7246 |
| language | English |
| last_indexed | 2024-04-11T05:54:43Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Drug and Alcohol Dependence Reports |
| spelling | doaj.art-c4ece3b07ddd429e9837d324c954c0682022-12-22T04:41:57ZengElsevierDrug and Alcohol Dependence Reports2772-72462022-12-015100098Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues.Paul S. Regier0Michael J. Gawrysiak1Kanchana Jagannathan2Anna Rose Childress3Teresa R. Franklin4Reagan R. Wetherill5University of Pennsylvania, Perelman School of Medicine, 3535 Market Street, Philadelphia, PA, 19104, United States; Corresponding author.University of Pennsylvania, Perelman School of Medicine, 3535 Market Street, Philadelphia, PA, 19104, United States; West Chester University of Pennsylvania, 125 West Rosedale Avenue, 19383, United StatesUniversity of Pennsylvania, Perelman School of Medicine, 3535 Market Street, Philadelphia, PA, 19104, United StatesUniversity of Pennsylvania, Perelman School of Medicine, 3535 Market Street, Philadelphia, PA, 19104, United StatesUniversity of Pennsylvania, Perelman School of Medicine, 3535 Market Street, Philadelphia, PA, 19104, United StatesUniversity of Pennsylvania, Perelman School of Medicine, 3535 Market Street, Philadelphia, PA, 19104, United StatesThe relationship of cannabis-use disorder and trauma exposure at the level of the brain is not well-understood. Cue-reactivity paradigms have largely focused on characterizing aberrant subcortical function by averaging across the entire task. However, changes across the task, including a non-habituating amygdala response (NHAR), may be a useful biomarker for relapse vulnerability and other pathology. This secondary analysis utilized existing fMRI data from a CUD population with (TR-Y, n = 18) or without trauma (TR-N, n = 15). Amygdala reactivity to novel and repeated aversive cues was examined between TR-Y vs. TR-N groups, using a repeated measures ANOVA. Analysis revealed a significant interaction between TR-Y vs. TR-N and amygdala response to novel vs. repeated cues in the amygdala (right: F (1,31) = 5.31, p = 0.028; left: F (1,31) = 7.42, p = 0.011). In the TR-Y group, a NHAR was evident, while the TR-N group exhibited amygdala habituation, resulting in a significant difference between groups of amygdala reactivity to repeated cues (right: p = 0.002; left: p < 0.001). The NHAR in the TR-Y (but not TR-N) group was significantly correlated with higher cannabis craving scores, yielding a significant group difference (z = 2.1, p = 0.018). Results suggest trauma interacts with the brain's sensitivity to aversive cues, offering a neural explanation for the relationship between trauma and CUD vulnerability. These findings suggest the importance of considering the temporal dynamics of cue reactivity and trauma history in future studies and treatment planning, as this distinction may help decrease relapse vulnerability.http://www.sciencedirect.com/science/article/pii/S2772724622000737CannabisTraumaAmygdalaCue-reactivityTemporal dynamics |
| spellingShingle | Paul S. Regier Michael J. Gawrysiak Kanchana Jagannathan Anna Rose Childress Teresa R. Franklin Reagan R. Wetherill Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues. Drug and Alcohol Dependence Reports Cannabis Trauma Amygdala Cue-reactivity Temporal dynamics |
| title | Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues. |
| title_full | Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues. |
| title_fullStr | Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues. |
| title_full_unstemmed | Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues. |
| title_short | Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues. |
| title_sort | trauma exposure among cannabis use disorder individuals was associated with a craving correlated non habituating amygdala response to aversive cues |
| topic | Cannabis Trauma Amygdala Cue-reactivity Temporal dynamics |
| url | http://www.sciencedirect.com/science/article/pii/S2772724622000737 |
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