Coexpression of novel furin-resistant LPL variants with lipase maturation factor 1 enhances LPL secretion and activity

Coexpression of novel furin-resistant LPL variants with lipase maturation factor 1 enhances LPL secretion and activity

LPL is a secreted enzyme that hydrolyzes triglycerides from circulating lipoproteins. Individuals lacking LPL suffer from severe hypertriglyceridemia, a risk factor for acute pancreatitis. One potential treatment is to administer recombinant LPL as a protein therapeutic. However, use of LPL as a pro...

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Bibliographic Details
Main Authors:	Ming Jing Wu, Anna Wolska, Benjamin S. Roberts, Ellis M. Pearson, Aspen R. Gutgsell, Alan T. Remaley, Saskia B. Neher
Format:	Article
Language:	English
Published:	Elsevier 2018-12-01
Series:	Journal of Lipid Research
Subjects:	lipoprotein lipase protein purification trafficking
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520341705

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