Downregulation of Swine Leukocyte Antigen Expression Decreases the Strength of Xenogeneic Immune Responses towards Renal Proximal Tubular Epithelial Cells

Downregulation of Swine Leukocyte Antigen Expression Decreases the Strength of Xenogeneic Immune Responses towards Renal Proximal Tubular Epithelial Cells

Xenotransplantation reemerged as a promising alternative to conventional transplantation enlarging the available organ pool. However, success of xenotransplantation depends on the design and selection of specific genetic modifications and on the development of robust assays allowing for a precise as...

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Bibliographic Details
Main Authors: Katharina Schmalkuche, Reinhard Schwinzer, Nadine Wenzel, Emilio Valdivia, Björn Petersen, Rainer Blasczyk, Constanca Figueiredo
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
SLA
RNAi
kidney
xenotransplantation
immortalization
Online Access:https://www.mdpi.com/1422-0067/24/16/12711

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