Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea
The Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia. Since the introduction of a universal JE vaccination program and urbanization of Korea, the incidence of JE has dramatically decreased in Korea. However, recent JE cases have occurred, predominantl...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2022-03-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2020-01984.pdf |
| _version_ | 1828544033785380864 |
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| author | Byung Ok Kwak Young Jin Hong Dong Hyun Kim |
| author_facet | Byung Ok Kwak Young Jin Hong Dong Hyun Kim |
| author_sort | Byung Ok Kwak |
| collection | DOAJ |
| description | The Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia. Since the introduction of a universal JE vaccination program and urbanization of Korea, the incidence of JE has dramatically decreased in Korea. However, recent JE cases have occurred, predominantly among unvaccinated adults and with a shift in age distribution. Here we aimed to review the changes in age-specific JE seroprevalence over time and discuss the implications of JE vaccination programs in Korea. Following the last epidemic in 1982–1983, mandatory vaccination for all children aged 3–15 years was conducted annually until 1994. However, JE has reemerged, predominantly affecting unvaccinated adults aged 40 years or older and demonstrating a shift in age distribution toward older populations. The age-specific seroprevalence of the JE virus in Korea has changed noticeably over time. Seropositivity in children and adolescents increased from 10%–59% in the 1970s to 90%–92% in the 1980s after the implementation of the JE vaccination program and increased further to 98% in 2012. No age-specific difference in the seroprevalence of JE was found, and appropriate levels of immunity to JE were maintained for all age groups. Continuous surveillance of the seroprevalence of JE is essential to establish a proper immunization policy in Korea. |
| first_indexed | 2024-12-12T02:22:58Z |
| format | Article |
| id | doaj.art-c4f043ce25144192a6c8b46bd183ef5c |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-12-12T02:22:58Z |
| publishDate | 2022-03-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-c4f043ce25144192a6c8b46bd183ef5c2022-12-22T00:41:37ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482022-03-0165310811410.3345/cep.2020.0198420125555463Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in KoreaByung Ok Kwak0Young Jin Hong1Dong Hyun Kim2 Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea Department of Pediatrics, Inha University School of Medicine, Incheon, Korea Department of Pediatrics, Inha University School of Medicine, Incheon, KoreaThe Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia. Since the introduction of a universal JE vaccination program and urbanization of Korea, the incidence of JE has dramatically decreased in Korea. However, recent JE cases have occurred, predominantly among unvaccinated adults and with a shift in age distribution. Here we aimed to review the changes in age-specific JE seroprevalence over time and discuss the implications of JE vaccination programs in Korea. Following the last epidemic in 1982–1983, mandatory vaccination for all children aged 3–15 years was conducted annually until 1994. However, JE has reemerged, predominantly affecting unvaccinated adults aged 40 years or older and demonstrating a shift in age distribution toward older populations. The age-specific seroprevalence of the JE virus in Korea has changed noticeably over time. Seropositivity in children and adolescents increased from 10%–59% in the 1970s to 90%–92% in the 1980s after the implementation of the JE vaccination program and increased further to 98% in 2012. No age-specific difference in the seroprevalence of JE was found, and appropriate levels of immunity to JE were maintained for all age groups. Continuous surveillance of the seroprevalence of JE is essential to establish a proper immunization policy in Korea.http://www.e-cep.org/upload/pdf/cep-2020-01984.pdfjapanese encephalitis vaccinekoreaneutralizing antibodiesseroprevalence |
| spellingShingle | Byung Ok Kwak Young Jin Hong Dong Hyun Kim Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea Clinical and Experimental Pediatrics japanese encephalitis vaccine korea neutralizing antibodies seroprevalence |
| title | Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea |
| title_full | Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea |
| title_fullStr | Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea |
| title_full_unstemmed | Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea |
| title_short | Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea |
| title_sort | changes in age specific seroprevalence of japanese encephalitis virus and impact of japanese encephalitis vaccine in korea |
| topic | japanese encephalitis vaccine korea neutralizing antibodies seroprevalence |
| url | http://www.e-cep.org/upload/pdf/cep-2020-01984.pdf |
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