Linking Pregnancy and Long-Term Health: The Impact of Cardiovascular Risk on Telomere Shortening in Pregnant Women
<i>Background and Objectives</i>: Telomeres are repetitive DNA sequences located at the end of chromosomes that play a crucial role in maintaining chromosomal stability. Shortening of telomeres has been associated with an increased risk of cardiovascular disease. The aim of this study wa...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/6/1012 |
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| author | Simona-Alina Abu-Awwad Marius Craina Adrian Gluhovschi Paula Diana Ciordas Catalin Marian Lioara Boscu Elena Bernad Mircea Iurciuc Ahmed Abu-Awwad Stela Iurciuc Anca Laura Maghiari |
| author_facet | Simona-Alina Abu-Awwad Marius Craina Adrian Gluhovschi Paula Diana Ciordas Catalin Marian Lioara Boscu Elena Bernad Mircea Iurciuc Ahmed Abu-Awwad Stela Iurciuc Anca Laura Maghiari |
| author_sort | Simona-Alina Abu-Awwad |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Telomeres are repetitive DNA sequences located at the end of chromosomes that play a crucial role in maintaining chromosomal stability. Shortening of telomeres has been associated with an increased risk of cardiovascular disease. The aim of this study was to investigate whether the length of telomeres in pregnant women with cardiovascular risk is shorter compared to those without cardiovascular risk. <i>Materials and Methods</i>: A total of 68 participants were enrolled, including 30 pregnant women with cardiovascular risk and 38 without cardiovascular risk, who were followed-up during their pregnancy between 2020 and 2022 at the Obstetrical and Gynecology Department of the “Pius Brînzeu” Emergency County Clinical Hospital in Timişoara, Romania. All included women underwent delivery via cesarean section at the same medical institution. The telomere length was measured in each participant using quantitative Polymerase chain reaction (PCR). <i>Results</i>: The results showed that the telomere length was negatively correlated with cardiovascular risk in pregnant women, with significantly shorter telomeres observed in the cardiovascular risk group (mean telomere length = 0.3537) compared to the group without cardiovascular risk (mean telomere length = 0.5728) (<i>p</i> = 0.0458). <i>Conclusions</i>: These findings suggest that cardiovascular risk during pregnancy may be associated with accelerated telomere shortening, which could have implications for the long-term health of both the mother and the child. Further research is needed to investigate the potential mechanisms underlying this association and to identify interventions that may mitigate the negative effects of cardiovascular risk on the telomere length during pregnancy. |
| first_indexed | 2024-03-11T02:11:41Z |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T02:11:41Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-c4f0926112594d0d9a6db51be2aa50152023-11-18T11:30:11ZengMDPI AGMedicina1010-660X1648-91442023-05-01596101210.3390/medicina59061012Linking Pregnancy and Long-Term Health: The Impact of Cardiovascular Risk on Telomere Shortening in Pregnant WomenSimona-Alina Abu-Awwad0Marius Craina1Adrian Gluhovschi2Paula Diana Ciordas3Catalin Marian4Lioara Boscu5Elena Bernad6Mircea Iurciuc7Ahmed Abu-Awwad8Stela Iurciuc9Anca Laura Maghiari10Doctoral School, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania“Clinic of Obstetrics and Gynecology”, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania“Clinic of Obstetrics and Gynecology”, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, RomaniaDepartament IV—Discipline of Biochemistry, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartament IV—Discipline of Biochemistry, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania“Clinic of Obstetrics and Gynecology”, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania“Clinic of Obstetrics and Gynecology”, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania“Clinic of Obstetrics and Gynecology”, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania<i>Background and Objectives</i>: Telomeres are repetitive DNA sequences located at the end of chromosomes that play a crucial role in maintaining chromosomal stability. Shortening of telomeres has been associated with an increased risk of cardiovascular disease. The aim of this study was to investigate whether the length of telomeres in pregnant women with cardiovascular risk is shorter compared to those without cardiovascular risk. <i>Materials and Methods</i>: A total of 68 participants were enrolled, including 30 pregnant women with cardiovascular risk and 38 without cardiovascular risk, who were followed-up during their pregnancy between 2020 and 2022 at the Obstetrical and Gynecology Department of the “Pius Brînzeu” Emergency County Clinical Hospital in Timişoara, Romania. All included women underwent delivery via cesarean section at the same medical institution. The telomere length was measured in each participant using quantitative Polymerase chain reaction (PCR). <i>Results</i>: The results showed that the telomere length was negatively correlated with cardiovascular risk in pregnant women, with significantly shorter telomeres observed in the cardiovascular risk group (mean telomere length = 0.3537) compared to the group without cardiovascular risk (mean telomere length = 0.5728) (<i>p</i> = 0.0458). <i>Conclusions</i>: These findings suggest that cardiovascular risk during pregnancy may be associated with accelerated telomere shortening, which could have implications for the long-term health of both the mother and the child. Further research is needed to investigate the potential mechanisms underlying this association and to identify interventions that may mitigate the negative effects of cardiovascular risk on the telomere length during pregnancy.https://www.mdpi.com/1648-9144/59/6/1012pregnancypregnant womanhigh riskpathologycardiovascular diseasetelomere |
| spellingShingle | Simona-Alina Abu-Awwad Marius Craina Adrian Gluhovschi Paula Diana Ciordas Catalin Marian Lioara Boscu Elena Bernad Mircea Iurciuc Ahmed Abu-Awwad Stela Iurciuc Anca Laura Maghiari Linking Pregnancy and Long-Term Health: The Impact of Cardiovascular Risk on Telomere Shortening in Pregnant Women Medicina pregnancy pregnant woman high risk pathology cardiovascular disease telomere |
| title | Linking Pregnancy and Long-Term Health: The Impact of Cardiovascular Risk on Telomere Shortening in Pregnant Women |
| title_full | Linking Pregnancy and Long-Term Health: The Impact of Cardiovascular Risk on Telomere Shortening in Pregnant Women |
| title_fullStr | Linking Pregnancy and Long-Term Health: The Impact of Cardiovascular Risk on Telomere Shortening in Pregnant Women |
| title_full_unstemmed | Linking Pregnancy and Long-Term Health: The Impact of Cardiovascular Risk on Telomere Shortening in Pregnant Women |
| title_short | Linking Pregnancy and Long-Term Health: The Impact of Cardiovascular Risk on Telomere Shortening in Pregnant Women |
| title_sort | linking pregnancy and long term health the impact of cardiovascular risk on telomere shortening in pregnant women |
| topic | pregnancy pregnant woman high risk pathology cardiovascular disease telomere |
| url | https://www.mdpi.com/1648-9144/59/6/1012 |
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