Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice

Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice

The COVID-19 pandemic caused by the SARS-CoV-2 infection induced lung inflammation characterized by cytokine storm and fulminant immune response of both resident and migrated immune cells, accelerating alveolar damage. In this work we identified members of the matrix metalloprotease (MMPs) family as...

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Bibliographic Details
Main Authors: Hila Gutman, Moshe Aftalion, Sharon Melamed, Boaz Politi, Reinat Nevo, Sapir Havusha-Laufer, Hagit Achdout, David Gur, Tomer Israely, Shlomit Dachir, Emanuelle Mamroud, Irit Sagi, Yaron Vagima
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
COVID-19
extra-cellular matrix (ECM)
K18-hACE2
matrix-metalloproteases (MMP)
SARS-CoV-2
Online Access:https://www.mdpi.com/1999-4915/14/8/1627

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