Impaired Terminal Erythroid Maturation in β<sup>0</sup>-Thalassemia/HbE Patients with Different Clinical Severity

Impaired Terminal Erythroid Maturation in β<sup>0</sup>-Thalassemia/HbE Patients with Different Clinical Severity

Anemia in β-thalassemia is associated with ineffective erythropoiesis and a shortened lifespan of erythroid cells. The limited differentiation of β-thalassemic erythroblasts has been documented, but the characteristic feature of terminal erythroid maturation and its physiological relevance are not c...

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Bibliographic Details
Main Authors: Thunwarat Suriyun, Pranee Winichagoon, Suthat Fucharoen, Orapan Sripichai
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Journal of Clinical Medicine
Subjects:
β-thalassemia
hemoglobin
reticulocyte
mitochondria
erythropoiesis
Online Access:https://www.mdpi.com/2077-0383/11/7/1755

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