Enhanced Efficacy of Radiopharmaceuticals When Using Technetium-99m-Labeled Liposomal Agents: Synthesis and Pharmacokinetic Properties

Enhanced Efficacy of Radiopharmaceuticals When Using Technetium-99m-Labeled Liposomal Agents: Synthesis and Pharmacokinetic Properties

Challenges posed by the retention of radiopharmaceuticals in unintended organs affect the quality of patient procedures when undergoing diagnostics and therapeutics. The aim of this study was to formulate a suitable tracer encapsulated in liposomes using different techniques and compounds to enhance...

Full description

Bibliographic Details
Main Authors:	Anfal M. Alkandari, Yasser M. Alsayed, Atallah M. El-Hanbaly
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	Biomedicines
Subjects:	liposome chromatography pharmacokinetics <sup>99m</sup>Tc radiopharmaceutical
Online Access:	https://www.mdpi.com/2227-9059/10/11/2994

Similar Items

Technetium Complexes and Radiopharmaceuticals with Scorpionate Ligands
by: Petra Martini, et al.
Published: (2018-08-01)

Effect of High Activity Technetium-99m on the Stability of Tc-99m Tetrofosmin as Injectable radiopharmaceuticals
by: Widyastuti Widjaksana, et al.
Published: (2018-05-01)

Alternative chromatographic system for the quality control of lipophilic technetium-99m radiopharmaceuticals such as [99mTc(MIBI)6]+
by: D.P. Faria, et al.
Published: (2015-01-01)

Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
by: Erik V. Johnstone, et al.
Published: (2023-02-01)

Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
by: Adriano Duatti, et al.
Published: (2002-09-01)

Preparation and evaluation of modified composition for lyophilized kits of [Cu(MIBI)4]BF4 for [99mTc] technetium labeling
by: Marisa de Jesus de C. Lima, et al.
Published: (2005-10-01)

Chemical and Physical Characterisation of Macroaggregated Human Serum Albumin: Strength and Specificity of Bonds with <sup>99m</sup>Tc and <sup>68</sup>Ga
by: Letizia Canziani, et al.
Published: (2022-01-01)

Effect of Radioactivity of Technetium-99m on the Autosterilization Process of non-sterile Tetrofosmin Kits
by: Widyastuti Widyastuti, et al.
Published: (2017-03-01)

Radioactivity distribution in the blood and urine of patients receiving systemic therapy with a <sup>177</sup>Lu radiopharmaceutical and local (intra-articular) therapy with a <sup>188</sup>Re radiopharmaceutical
by: E. D. Stepchenkova, et al.
Published: (2022-12-01)

Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review
by: Ana Cláudia Camargo Miranda, et al.

A new two-strip TLC method for the quality control of technetium-99m mercaptoacetyl-triglycine (99mTc-MAG3)
by: Marietta Straub, et al.
Published: (2018-03-01)

Zn Complex of Diaminedithiol Tetradentate Ligand as a Stable Precursor for <sup>99m</sup>Tc-Labeled Compounds
by: Shinobu Oshikiri, et al.
Published: (2020-01-01)

Development of in-House Synthesis and Quality Control of [<sup>99m</sup>Tc]Tc-PSMA-I&S
by: Elisabeth Plhak, et al.
Published: (2023-01-01)

Developing a Chromatographic <sup>99m</sup>Tc Generator Based on Mesoporous Alumina for Industrial Radiotracer Applications: A Potential New Generation Sorbent for Using Low-Specific-Activity <sup>99</sup>Mo
by: Mohamed F. Nawar, et al.
Published: (2022-09-01)

Sorbitol as a Polar Pharmacological Modifier to Enhance the Hydrophilicity of <sup>99m</sup>Tc-Tricarbonyl-Based Radiopharmaceuticals
by: Carolina Giammei, et al.
Published: (2020-06-01)

Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research
by: Cristina Bolzati, et al.
Published: (2019-12-01)

Preparation, Characterization, and In Vivo Pharmacokinetic Study of the Supercritical Fluid-Processed Liposomal Amphotericin B
by: Chang-baek Lim, et al.
Published: (2019-11-01)

Development of ciprofloxacin radiopharmaceutical formulation in single vial
by: Nurlaila Z, et al.
Published: (2010-04-01)

Evaluation of radiochemical purities of some radiopharmaceuticals in Shiraz Namazi teaching hospital
by: Hossein Sadeghpour, et al.
Published: (2015-03-01)

Pharmacokinetic Studies of Radiopharmaceuticals
by: A. S. Lunev, et al.
Published: (2022-12-01)

[<sup>99m</sup>Tc]Tc-Labeled Plectin-Targeting Peptide as a Novel SPECT Probe for Tumor Imaging
by: Jiali Gong, et al.
Published: (2022-05-01)

Technetium-99m in production and use
by: Vučina Jurij, et al.
Published: (2009-01-01)

[<sup>99m</sup>Tc]Tc-iFAP/SPECT Tumor Stroma Imaging: Acquisition and Analysis of Clinical Images in Six Different Cancer Entities
by: Paola Vallejo-Armenta, et al.
Published: (2022-06-01)

Technetium-Radiolabeled Mannose-Functionalized Gold Nanoparticles as Nanoprobes for Sentinel Lymph Node Detection
by: Oscar J. Estudiante-Mariquez, et al.
Published: (2020-04-01)

<sup>99</sup>Tc-MDP inhibits corneal neovascularization induced by alkali burn in rats
by: Ning Kong, et al.
Published: (2013-08-01)

Radiolabeling of Ceftriaxone with 99mTc as a Targeting Radiopharmaceutical for Staphylococcus Aureus Detection in Mouse Model
by: Akram Fazli, et al.
Published: (2012-03-01)

Development and Evaluation of <sup>99m</sup>Tc Tricarbonyl Complexes Derived from Flutamide with Affinity for Androgen Receptor
by: María Elena Cardoso, et al.
Published: (2023-01-01)

Radiolabeling of Platelets with <sup>99m</sup>Tc-HYNIC-Duramycin for In Vivo Imaging Studies
by: Keresztély Merkel, et al.
Published: (2023-12-01)

Drug interaction with radiopharmaceuticals: effect on the labeling of red blood cells with technetium-99m and on the bioavailability of radiopharmaceuticals
by: Maria Luisa Gomes, et al.
Published: (2002-09-01)

Genotoxicity Associated with <sup>131</sup>I and <sup>99m</sup>Tc Exposure in Nuclear Medicine Staff: A Physical and Biological Monitoring Study
by: Justyna Miszczyk, et al.
Published: (2022-05-01)

Development and Characterization of <sup>99m</sup>Tc-scFvD2B as a Potential Radiopharmaceutical for SPECT Imaging of Prostate Cancer
by: Cristina Bolzati, et al.
Published: (2023-12-01)

Radiolabeling of Ciprofloxacin with Technetium-99m, Quality Control and Biodistribution
by: S.F Mirshojaei, et al.
Published: (2011-05-01)

<sup>99m</sup>Tc-Labeled FAPI SPECT Imaging in Idiopathic Pulmonary Fibrosis: Preliminary Results
by: Yu Liu, et al.
Published: (2023-10-01)

[<sup>99m</sup>Tc]Tc-DB1 Mimics with Different-Length PEG Spacers: Preclinical Comparison in GRPR-Positive Models
by: Panagiotis Kanellopoulos, et al.
Published: (2020-07-01)

Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with <sup>99m</sup>Tc for Radionuclide Imaging of HER2 Expression in Cancer
by: Mariia Larkina, et al.
Published: (2022-11-01)

[<sup>18</sup>F]fluoride Activation and <sup>18</sup>F-Labelling in Hydrous Conditions—Towards a Microfluidic Synthesis of PET Radiopharmaceuticals
by: Olga Ovdiichuk, et al.
Published: (2023-12-01)

[<sup>99m</sup>Tc]Tc-iFAP Radioligand for SPECT/CT Imaging of the Tumor Microenvironment: Kinetics, Radiation Dosimetry, and Imaging in Patients
by: Luis Coria-Domínguez, et al.
Published: (2022-05-01)

Production and Quality Control of Technetium-99m Radiolabeled Monoclonal Antibody
by: M.H. Babaei, Ph.D., et al.
Published: (2007-01-01)

Study on the Effect of Gamma-Ray Irradiation on the Adsorption of <sup>99</sup>Tc and Re by a Silica-Based Pyridine Resin
by: Hongji Sang, et al.
Published: (2022-10-01)

Preparation and Biological Evaluation of [<sup>99m</sup>Tc]Tc-CNGU as a PSMA-Targeted Radiotracer for the Imaging of Prostate Cancer
by: Di Xiao, et al.
Published: (2020-11-01)