Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage
Since mass effect and secondary brain injuries persist in the pathogenesis of intracerebral hemorrhage, hematoma evacuation within a limited time is reasonable. However, it is complex to define an accurate therapeutic time window (TTW) for hematoma evacuation. In this review, studies about TTW were...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2020-09-01
|
| Series: | Brain Hemorrhages |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589238X20300310 |
| _version_ | 1828900396688474112 |
|---|---|
| author | Guangyu Guo Wenliang Guo Yangyang Feng Hong Deng Ping Zhang Yingxin Tang Guofeng Wu Qi Li Chao Pan Zhouping Tang |
| author_facet | Guangyu Guo Wenliang Guo Yangyang Feng Hong Deng Ping Zhang Yingxin Tang Guofeng Wu Qi Li Chao Pan Zhouping Tang |
| author_sort | Guangyu Guo |
| collection | DOAJ |
| description | Since mass effect and secondary brain injuries persist in the pathogenesis of intracerebral hemorrhage, hematoma evacuation within a limited time is reasonable. However, it is complex to define an accurate therapeutic time window (TTW) for hematoma evacuation. In this review, studies about TTW were discussed from four aspects: histopathology, molecular pathophysiology, neuroimaging and clinical outcomes. Animal experiments indicated that 6–12 h is the pathophysiological TTW of minimally invasive surgery. Clinical trials suggested that there is a correlation between TTW and clinical outcomes, while the exact TTW is still unclear due to lack of sufficient clinical studies, which deserves further investigation. |
| first_indexed | 2024-12-13T15:46:30Z |
| format | Article |
| id | doaj.art-c4f4108d32c44dca9408f3b8943eeec1 |
| institution | Directory Open Access Journal |
| issn | 2589-238X |
| language | English |
| last_indexed | 2024-12-13T15:46:30Z |
| publishDate | 2020-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Brain Hemorrhages |
| spelling | doaj.art-c4f4108d32c44dca9408f3b8943eeec12022-12-21T23:39:41ZengKeAi Communications Co., Ltd.Brain Hemorrhages2589-238X2020-09-0113158160Therapeutic time window of minimally invasive surgery for intracerebral hemorrhageGuangyu Guo0Wenliang Guo1Yangyang Feng2Hong Deng3Ping Zhang4Yingxin Tang5Guofeng Wu6Qi Li7Chao Pan8Zhouping Tang9Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaEmergency Department, Affiliated Hospital of Guiyang Medical University, Guiyang City, Guizhou Province, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Corresponding author.Since mass effect and secondary brain injuries persist in the pathogenesis of intracerebral hemorrhage, hematoma evacuation within a limited time is reasonable. However, it is complex to define an accurate therapeutic time window (TTW) for hematoma evacuation. In this review, studies about TTW were discussed from four aspects: histopathology, molecular pathophysiology, neuroimaging and clinical outcomes. Animal experiments indicated that 6–12 h is the pathophysiological TTW of minimally invasive surgery. Clinical trials suggested that there is a correlation between TTW and clinical outcomes, while the exact TTW is still unclear due to lack of sufficient clinical studies, which deserves further investigation.http://www.sciencedirect.com/science/article/pii/S2589238X20300310Intracerebral hemorrhageTherapeutic time windowMinimally invasive surgery |
| spellingShingle | Guangyu Guo Wenliang Guo Yangyang Feng Hong Deng Ping Zhang Yingxin Tang Guofeng Wu Qi Li Chao Pan Zhouping Tang Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage Brain Hemorrhages Intracerebral hemorrhage Therapeutic time window Minimally invasive surgery |
| title | Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage |
| title_full | Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage |
| title_fullStr | Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage |
| title_full_unstemmed | Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage |
| title_short | Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage |
| title_sort | therapeutic time window of minimally invasive surgery for intracerebral hemorrhage |
| topic | Intracerebral hemorrhage Therapeutic time window Minimally invasive surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2589238X20300310 |
| work_keys_str_mv | AT guangyuguo therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT wenliangguo therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT yangyangfeng therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT hongdeng therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT pingzhang therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT yingxintang therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT guofengwu therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT qili therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT chaopan therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage AT zhoupingtang therapeutictimewindowofminimallyinvasivesurgeryforintracerebralhemorrhage |