Tuberculin skin test and boosted reactions among newly employed healthcare workers: an observational study.
<h4>Objective</h4>To evaluate the prevalence of and factors associated with latent tuberculosis infection (LTBI) based on the tuberculin skin test (TST) and to estimate the boosted reaction rate among newly employed healthcare workers (HCWs).<h4>Design</h4>Newly employed HCWs...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717631/pdf/?tool=EBI |
| _version_ | 1818701586823643136 |
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| author | Song Yee Kim Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Dongeun Yong Hyun Sook Kim Kyungwon Lee Young Ae Kang |
| author_facet | Song Yee Kim Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Dongeun Yong Hyun Sook Kim Kyungwon Lee Young Ae Kang |
| author_sort | Song Yee Kim |
| collection | DOAJ |
| description | <h4>Objective</h4>To evaluate the prevalence of and factors associated with latent tuberculosis infection (LTBI) based on the tuberculin skin test (TST) and to estimate the boosted reaction rate among newly employed healthcare workers (HCWs).<h4>Design</h4>Newly employed HCWs between January 2010 and July 2012 at Severance Hospital in South Korea were enrolled in this study. A one-step TST was conducted before October 2011, and a two-step TST after October 2011.<h4>Results</h4>Of 2132 participants, 778 (36.5%) had positive TST results. Being older (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.06-1.13, P<0.001), male (OR 1.78, 95% CI 1.21-2.62, P = 0.003), rejoining the hospital workforce (OR 1.58, 95% CI 1.04-2.40, P = 0.032), and having a previous history of tuberculosis (TB) (OR 18.21, 95% CI 2.15-154.10, P = 0.008) during the one-step period, and being older (OR 1.15, 95% CI 1.10-1.21, P<0.001) during the two-step period were significantly associated with a positive TST. A two-step TST was performed in 556 HCWs, and a boosted reaction was observed in 79 (14.2%). The induration size on the first TST (5-9-mm group) was the only factor associated with a boosted reaction on the second TST.<h4>Conclusions</h4>The prevalence of LTBI based on the TST among newly employed HCWs was high. The boosted reaction rate on two-step TST was not low; therefore, the use of two-step TST may be necessary for regular monitoring in countries with an intermediate TB burden and a high rate of Bacillus Calmette-Guérin vaccination. |
| first_indexed | 2024-12-17T15:23:12Z |
| format | Article |
| id | doaj.art-c4f7e5396d414ed38ef4fb2c3aece830 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T15:23:12Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-c4f7e5396d414ed38ef4fb2c3aece8302022-12-21T21:43:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6456310.1371/journal.pone.0064563Tuberculin skin test and boosted reactions among newly employed healthcare workers: an observational study.Song Yee KimMoo Suk ParkYoung Sam KimSe Kyu KimJoon ChangDongeun YongHyun Sook KimKyungwon LeeYoung Ae Kang<h4>Objective</h4>To evaluate the prevalence of and factors associated with latent tuberculosis infection (LTBI) based on the tuberculin skin test (TST) and to estimate the boosted reaction rate among newly employed healthcare workers (HCWs).<h4>Design</h4>Newly employed HCWs between January 2010 and July 2012 at Severance Hospital in South Korea were enrolled in this study. A one-step TST was conducted before October 2011, and a two-step TST after October 2011.<h4>Results</h4>Of 2132 participants, 778 (36.5%) had positive TST results. Being older (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.06-1.13, P<0.001), male (OR 1.78, 95% CI 1.21-2.62, P = 0.003), rejoining the hospital workforce (OR 1.58, 95% CI 1.04-2.40, P = 0.032), and having a previous history of tuberculosis (TB) (OR 18.21, 95% CI 2.15-154.10, P = 0.008) during the one-step period, and being older (OR 1.15, 95% CI 1.10-1.21, P<0.001) during the two-step period were significantly associated with a positive TST. A two-step TST was performed in 556 HCWs, and a boosted reaction was observed in 79 (14.2%). The induration size on the first TST (5-9-mm group) was the only factor associated with a boosted reaction on the second TST.<h4>Conclusions</h4>The prevalence of LTBI based on the TST among newly employed HCWs was high. The boosted reaction rate on two-step TST was not low; therefore, the use of two-step TST may be necessary for regular monitoring in countries with an intermediate TB burden and a high rate of Bacillus Calmette-Guérin vaccination.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717631/pdf/?tool=EBI |
| spellingShingle | Song Yee Kim Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Dongeun Yong Hyun Sook Kim Kyungwon Lee Young Ae Kang Tuberculin skin test and boosted reactions among newly employed healthcare workers: an observational study. PLoS ONE |
| title | Tuberculin skin test and boosted reactions among newly employed healthcare workers: an observational study. |
| title_full | Tuberculin skin test and boosted reactions among newly employed healthcare workers: an observational study. |
| title_fullStr | Tuberculin skin test and boosted reactions among newly employed healthcare workers: an observational study. |
| title_full_unstemmed | Tuberculin skin test and boosted reactions among newly employed healthcare workers: an observational study. |
| title_short | Tuberculin skin test and boosted reactions among newly employed healthcare workers: an observational study. |
| title_sort | tuberculin skin test and boosted reactions among newly employed healthcare workers an observational study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717631/pdf/?tool=EBI |
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