Silica gel-assisted synthesis of benzo[b]thiophenes from o-(alkylsulfanyl)(ethynyl)benzenes
A variety of 2-substituted benzo[b]thiophenes were prepared from o-(alkylsulfanyl)(ethynyl)benzenes in the presence of silica gel under thermal conditions. Tertiary alkyl-substituted sulfanyl derivatives gave good results. Methylsulfanyl-substituted precursors also afforded benzo[b]thiophenes at hig...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622002065 |
| Summary: | A variety of 2-substituted benzo[b]thiophenes were prepared from o-(alkylsulfanyl)(ethynyl)benzenes in the presence of silica gel under thermal conditions. Tertiary alkyl-substituted sulfanyl derivatives gave good results. Methylsulfanyl-substituted precursors also afforded benzo[b]thiophenes at higher temperature. Effect of modified silica gel was evaluated and the mechanism of this method was discussed. This method was also applied to preparation of 2-substituted thieno[3,2-b]thiophenes, which gave moderate yields. |
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| ISSN: | 2211-7156 |