Lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosus
Aim. To investigate early atherosclerosis (AS) risk factors in patients with systemic lupus erythematosus (SLE) in respect to the presence of lupus nephritis (LN) and antiphospholipid (APL) antibodies. Material and methods. We analysed case histories of 137 SLE patients observed in E.M. Tareev clini...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2008-06-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30194 |
| _version_ | 1819065473533214720 |
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| author | S Iu Serikova N L Kozlovskaia E M Shilov |
| author_facet | S Iu Serikova N L Kozlovskaia E M Shilov |
| author_sort | S Iu Serikova |
| collection | DOAJ |
| description | Aim. To investigate early atherosclerosis (AS) risk factors in patients with systemic lupus erythematosus (SLE) in respect to the presence of lupus nephritis (LN) and antiphospholipid (APL) antibodies. Material and methods. We analysed case histories of 137 SLE patients observed in E.M. Tareev clinic from 1970 to 2006. AS manifestations were studied by echocardiography, ultrasonic dopplerog-raphy of the peripheral vessels, x-ray methods. AS was considered early if it arose at the age under 55 years. Patients with chronic renal failure were not included in the study. Results. AS development was seen in 54 (45%) patients, early symptoms appeared at the age of 25-68 years (mean 54 ± 10 years). In 37 (31%) patients AS symptoms manifested at the age under 55 years. Significant factors of early AS risk were age, hyperlipidemia, arterial hypertension, menopause for women, APL antibodies circulation, stage IV chronic disease of the kidneys, hyperuricemia, higher blood creatinine, mean dose of prednisolone over 15 mg/day, frequent elevation of the level of C-reactive protein. A direct correlation between lupus nephritis or nephrotic syndrome (NS) and early AS was not found. In LN hyperlipidemia occurred more often (p=0.055), lipids level and NS were not related during its remission. LN patients developed AS more frequently, had lower complement concentration in the end of the study, were treated with prednisolone more intensively than patients free of renal disease (p |
| first_indexed | 2024-12-21T15:47:01Z |
| format | Article |
| id | doaj.art-c4f9250d7f80449fbdb711c9a728f658 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T15:47:01Z |
| publishDate | 2008-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-c4f9250d7f80449fbdb711c9a728f6582022-12-21T18:58:20Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422008-06-01806525827221Lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosusS Iu SerikovaN L KozlovskaiaE M ShilovAim. To investigate early atherosclerosis (AS) risk factors in patients with systemic lupus erythematosus (SLE) in respect to the presence of lupus nephritis (LN) and antiphospholipid (APL) antibodies. Material and methods. We analysed case histories of 137 SLE patients observed in E.M. Tareev clinic from 1970 to 2006. AS manifestations were studied by echocardiography, ultrasonic dopplerog-raphy of the peripheral vessels, x-ray methods. AS was considered early if it arose at the age under 55 years. Patients with chronic renal failure were not included in the study. Results. AS development was seen in 54 (45%) patients, early symptoms appeared at the age of 25-68 years (mean 54 ± 10 years). In 37 (31%) patients AS symptoms manifested at the age under 55 years. Significant factors of early AS risk were age, hyperlipidemia, arterial hypertension, menopause for women, APL antibodies circulation, stage IV chronic disease of the kidneys, hyperuricemia, higher blood creatinine, mean dose of prednisolone over 15 mg/day, frequent elevation of the level of C-reactive protein. A direct correlation between lupus nephritis or nephrotic syndrome (NS) and early AS was not found. In LN hyperlipidemia occurred more often (p=0.055), lipids level and NS were not related during its remission. LN patients developed AS more frequently, had lower complement concentration in the end of the study, were treated with prednisolone more intensively than patients free of renal disease (phttps://ter-arkhiv.ru/0040-3660/article/view/30194atherosclerosissystemic lupus erythematosuslupus nephritisantiphospholipid antibodiesrisk factor |
| spellingShingle | S Iu Serikova N L Kozlovskaia E M Shilov Lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosus Терапевтический архив atherosclerosis systemic lupus erythematosus lupus nephritis antiphospholipid antibodies risk factor |
| title | Lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosus |
| title_full | Lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosus |
| title_fullStr | Lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosus |
| title_full_unstemmed | Lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosus |
| title_short | Lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosus |
| title_sort | lupus nephritis as a factor of atherosclerosis risk in patients with systemic lupus erythematosus |
| topic | atherosclerosis systemic lupus erythematosus lupus nephritis antiphospholipid antibodies risk factor |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30194 |
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