The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site

The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site

ABSTRACT The HIV-1 envelope glycoproteins (Env) undergo conformational changes upon interaction of the gp120 exterior glycoprotein with the CD4 receptor. The gp120 inner domain topological layers facilitate the transition of Env to the CD4-bound conformation. CD4 engages gp120 by introducing its phe...

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Bibliographic Details
Main Authors: Jérémie Prévost, William D. Tolbert, Halima Medjahed, Rebekah T. Sherburn, Navid Madani, Daria Zoubchenok, Gabrielle Gendron-Lepage, Althea E. Gaffney, Melissa C. Grenier, Sharon Kirk, Natasha Vergara, Changze Han, Brendan T. Mann, Agnès L. Chénine, Adel Ahmed, Irwin Chaiken, Frank Kirchhoff, Beatrice H. Hahn, Hillel Haim, Cameron F. Abrams, Amos B. Smith, Joseph Sodroski, Marzena Pazgier, Andrés Finzi
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
Env
gp120
CD4
CD4mc
CRF01_AE
ADCC
Online Access:https://journals.asm.org/doi/10.1128/mBio.00280-20

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