The Utility of Galectin-3 and HBME-1 Immunohistochemical Expression in Thyroid Cancer in the Maltese Population
Diagnosing thyroid carcinoma is not always easy on basic haemtoxylin and eosin staining since nuclear features are inconsistent and controversial. In view of this, studies on the role of immunohistochemical markers in the diagnosis of malignant thyroid carcinoma are necessary. Proposed immunohistoch...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Endocrines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-396X/3/2/21 |
| _version_ | 1827660670892507136 |
|---|---|
| author | Christine Vella Shawn Baldacchino Robert Formosa Josanne Vassallo |
| author_facet | Christine Vella Shawn Baldacchino Robert Formosa Josanne Vassallo |
| author_sort | Christine Vella |
| collection | DOAJ |
| description | Diagnosing thyroid carcinoma is not always easy on basic haemtoxylin and eosin staining since nuclear features are inconsistent and controversial. In view of this, studies on the role of immunohistochemical markers in the diagnosis of malignant thyroid carcinoma are necessary. Proposed immunohistochemical markers for papillary thyroid cancer include Hector Battifora mesothelial-1 (HBME-1), and Galectin-3 (Gal-3) which have been studied in this project. Immunohistochemical staining of fifty-eight formalin-fixed paraffin embedded surgically removed thyroid tissue from the years 2008 and 2013 was undertaken to determine the diagnostic accuracy of these two markers. We have concluded that both Gal-3 and HBME-1 are useful markers to aid in the diagnosis of papillary thyroid carcinoma and also in distinguishing between benign and malignant thyroid lesions. The sensitivity and specificity of Gal-3 over the 2years studied was found to be 96.2% and 92.6%, respectively, whilst HBME-1 was found to have sensitivity of 93.6% and specificity of 69.02%. |
| first_indexed | 2024-03-09T23:55:50Z |
| format | Article |
| id | doaj.art-c4fc783bd52548aeb2921795931cf26e |
| institution | Directory Open Access Journal |
| issn | 2673-396X |
| language | English |
| last_indexed | 2024-03-09T23:55:50Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj.art-c4fc783bd52548aeb2921795931cf26e2023-11-23T16:26:45ZengMDPI AGEndocrines2673-396X2022-05-013222523910.3390/endocrines3020021The Utility of Galectin-3 and HBME-1 Immunohistochemical Expression in Thyroid Cancer in the Maltese PopulationChristine Vella0Shawn Baldacchino1Robert Formosa2Josanne Vassallo3Department of Surgery, Faculty of Medicine and Surgery, Mater Dei Hospital, University of Malta, MSD 2090 Msida, MaltaDepartment of Pathology, Faculty of Medicine and Surgery, Mater Dei Hospital, University of Malta, MSD 2090 Msida, MaltaDepartment of Pathology, Faculty of Medicine and Surgery, Queen Mary University of London, VCT 2520 Victoria, MaltaDivision of Endocrinology, Department of Medicine, Faculty of Medicine and Surgery, Mater Dei Hospital, University of Malta, MSD 2090 Msida, MaltaDiagnosing thyroid carcinoma is not always easy on basic haemtoxylin and eosin staining since nuclear features are inconsistent and controversial. In view of this, studies on the role of immunohistochemical markers in the diagnosis of malignant thyroid carcinoma are necessary. Proposed immunohistochemical markers for papillary thyroid cancer include Hector Battifora mesothelial-1 (HBME-1), and Galectin-3 (Gal-3) which have been studied in this project. Immunohistochemical staining of fifty-eight formalin-fixed paraffin embedded surgically removed thyroid tissue from the years 2008 and 2013 was undertaken to determine the diagnostic accuracy of these two markers. We have concluded that both Gal-3 and HBME-1 are useful markers to aid in the diagnosis of papillary thyroid carcinoma and also in distinguishing between benign and malignant thyroid lesions. The sensitivity and specificity of Gal-3 over the 2years studied was found to be 96.2% and 92.6%, respectively, whilst HBME-1 was found to have sensitivity of 93.6% and specificity of 69.02%.https://www.mdpi.com/2673-396X/3/2/21immunohistochemistrythyroid cancermarkersHBME-1Galectin-3 |
| spellingShingle | Christine Vella Shawn Baldacchino Robert Formosa Josanne Vassallo The Utility of Galectin-3 and HBME-1 Immunohistochemical Expression in Thyroid Cancer in the Maltese Population Endocrines immunohistochemistry thyroid cancer markers HBME-1 Galectin-3 |
| title | The Utility of Galectin-3 and HBME-1 Immunohistochemical Expression in Thyroid Cancer in the Maltese Population |
| title_full | The Utility of Galectin-3 and HBME-1 Immunohistochemical Expression in Thyroid Cancer in the Maltese Population |
| title_fullStr | The Utility of Galectin-3 and HBME-1 Immunohistochemical Expression in Thyroid Cancer in the Maltese Population |
| title_full_unstemmed | The Utility of Galectin-3 and HBME-1 Immunohistochemical Expression in Thyroid Cancer in the Maltese Population |
| title_short | The Utility of Galectin-3 and HBME-1 Immunohistochemical Expression in Thyroid Cancer in the Maltese Population |
| title_sort | utility of galectin 3 and hbme 1 immunohistochemical expression in thyroid cancer in the maltese population |
| topic | immunohistochemistry thyroid cancer markers HBME-1 Galectin-3 |
| url | https://www.mdpi.com/2673-396X/3/2/21 |
| work_keys_str_mv | AT christinevella theutilityofgalectin3andhbme1immunohistochemicalexpressioninthyroidcancerinthemaltesepopulation AT shawnbaldacchino theutilityofgalectin3andhbme1immunohistochemicalexpressioninthyroidcancerinthemaltesepopulation AT robertformosa theutilityofgalectin3andhbme1immunohistochemicalexpressioninthyroidcancerinthemaltesepopulation AT josannevassallo theutilityofgalectin3andhbme1immunohistochemicalexpressioninthyroidcancerinthemaltesepopulation AT christinevella utilityofgalectin3andhbme1immunohistochemicalexpressioninthyroidcancerinthemaltesepopulation AT shawnbaldacchino utilityofgalectin3andhbme1immunohistochemicalexpressioninthyroidcancerinthemaltesepopulation AT robertformosa utilityofgalectin3andhbme1immunohistochemicalexpressioninthyroidcancerinthemaltesepopulation AT josannevassallo utilityofgalectin3andhbme1immunohistochemicalexpressioninthyroidcancerinthemaltesepopulation |