Trichosporon asahii Infection in an Extremely Preterm Infant in China

Na Wang1 *, Jing-yi Tang2 *, Zi Wang,3 Liu-yao Wang,4 Tian-tian Song,5 Bei-bei Li,5 Lin Wang5 1Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 2Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 3Department of Dermatolo...

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Main Authors: Wang N, Tang JY, Wang Z, Wang LY, Song TT, Li BB, Wang L
Format: Article
Language:English
Published: Dove Medical Press 2022-11-01
Series:Infection and Drug Resistance
Subjects:
Online Access:https://www.dovepress.com/trichosporon-asahii-infection-in-an-extremely-preterm-infant-in-china-peer-reviewed-fulltext-article-IDR
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author Wang N
Tang JY
Wang Z
Wang LY
Song TT
Li BB
Wang L
author_facet Wang N
Tang JY
Wang Z
Wang LY
Song TT
Li BB
Wang L
author_sort Wang N
collection DOAJ
description Na Wang1 *, Jing-yi Tang2 *, Zi Wang,3 Liu-yao Wang,4 Tian-tian Song,5 Bei-bei Li,5 Lin Wang5 1Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 2Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 3Department of Dermatology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, People’s Republic of China; 4Department of Pediatrics, Fuyong People’s Hospital, Shenzhen, People’s Republic of China; 5Department of Neonatology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Wang, Department of Neonatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email wl1894@yeah.netAbstract: Trichosporon asahii is an uncommon cause of fungal sepsis among neonates, but it is an important life-threatening opportunistic systemic pathogen. We report a case of T. asahii sepsis in a 980-g female baby born at 27 weeks of gestation. The extremely preterm initially presented with recurrent feeding intolerance and bloating; she subsequently developed oxygen saturation fluctuations, apnea, and a decreased heart rate. Blood culture was positive, and the causative agent was identified as T. asahii by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). According to reported minimum inhibitory concentration (MIC) values, the infant received a high dose of fluconazole (FLC, 12 mg/kg, qod) and was successfully treated.Keywords: preterm, Trichosporon asahii, fluconazole, voriconazole, China
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spelling doaj.art-c4fce8369bdd44719b9e87e44a1a77812022-12-22T04:38:23ZengDove Medical PressInfection and Drug Resistance1178-69732022-11-01Volume 156495649979460Trichosporon asahii Infection in an Extremely Preterm Infant in ChinaWang NTang JYWang ZWang LYSong TTLi BBWang LNa Wang1 *, Jing-yi Tang2 *, Zi Wang,3 Liu-yao Wang,4 Tian-tian Song,5 Bei-bei Li,5 Lin Wang5 1Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 2Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 3Department of Dermatology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, People’s Republic of China; 4Department of Pediatrics, Fuyong People’s Hospital, Shenzhen, People’s Republic of China; 5Department of Neonatology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Wang, Department of Neonatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email wl1894@yeah.netAbstract: Trichosporon asahii is an uncommon cause of fungal sepsis among neonates, but it is an important life-threatening opportunistic systemic pathogen. We report a case of T. asahii sepsis in a 980-g female baby born at 27 weeks of gestation. The extremely preterm initially presented with recurrent feeding intolerance and bloating; she subsequently developed oxygen saturation fluctuations, apnea, and a decreased heart rate. Blood culture was positive, and the causative agent was identified as T. asahii by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). According to reported minimum inhibitory concentration (MIC) values, the infant received a high dose of fluconazole (FLC, 12 mg/kg, qod) and was successfully treated.Keywords: preterm, Trichosporon asahii, fluconazole, voriconazole, Chinahttps://www.dovepress.com/trichosporon-asahii-infection-in-an-extremely-preterm-infant-in-china-peer-reviewed-fulltext-article-IDRpretermtrichosporon asahiifluconazolevoriconazolechina
spellingShingle Wang N
Tang JY
Wang Z
Wang LY
Song TT
Li BB
Wang L
Trichosporon asahii Infection in an Extremely Preterm Infant in China
Infection and Drug Resistance
preterm
trichosporon asahii
fluconazole
voriconazole
china
title Trichosporon asahii Infection in an Extremely Preterm Infant in China
title_full Trichosporon asahii Infection in an Extremely Preterm Infant in China
title_fullStr Trichosporon asahii Infection in an Extremely Preterm Infant in China
title_full_unstemmed Trichosporon asahii Infection in an Extremely Preterm Infant in China
title_short Trichosporon asahii Infection in an Extremely Preterm Infant in China
title_sort trichosporon asahii infection in an extremely preterm infant in china
topic preterm
trichosporon asahii
fluconazole
voriconazole
china
url https://www.dovepress.com/trichosporon-asahii-infection-in-an-extremely-preterm-infant-in-china-peer-reviewed-fulltext-article-IDR
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AT wangz trichosporonasahiiinfectioninanextremelypreterminfantinchina
AT wangly trichosporonasahiiinfectioninanextremelypreterminfantinchina
AT songtt trichosporonasahiiinfectioninanextremelypreterminfantinchina
AT libb trichosporonasahiiinfectioninanextremelypreterminfantinchina
AT wangl trichosporonasahiiinfectioninanextremelypreterminfantinchina