Trichosporon asahii Infection in an Extremely Preterm Infant in China
Na Wang1 *, Jing-yi Tang2 *, Zi Wang,3 Liu-yao Wang,4 Tian-tian Song,5 Bei-bei Li,5 Lin Wang5 1Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 2Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 3Department of Dermatolo...
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Dove Medical Press
2022-11-01
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Series: | Infection and Drug Resistance |
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Online Access: | https://www.dovepress.com/trichosporon-asahii-infection-in-an-extremely-preterm-infant-in-china-peer-reviewed-fulltext-article-IDR |
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author | Wang N Tang JY Wang Z Wang LY Song TT Li BB Wang L |
author_facet | Wang N Tang JY Wang Z Wang LY Song TT Li BB Wang L |
author_sort | Wang N |
collection | DOAJ |
description | Na Wang1 *, Jing-yi Tang2 *, Zi Wang,3 Liu-yao Wang,4 Tian-tian Song,5 Bei-bei Li,5 Lin Wang5 1Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 2Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 3Department of Dermatology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, People’s Republic of China; 4Department of Pediatrics, Fuyong People’s Hospital, Shenzhen, People’s Republic of China; 5Department of Neonatology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Wang, Department of Neonatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email wl1894@yeah.netAbstract: Trichosporon asahii is an uncommon cause of fungal sepsis among neonates, but it is an important life-threatening opportunistic systemic pathogen. We report a case of T. asahii sepsis in a 980-g female baby born at 27 weeks of gestation. The extremely preterm initially presented with recurrent feeding intolerance and bloating; she subsequently developed oxygen saturation fluctuations, apnea, and a decreased heart rate. Blood culture was positive, and the causative agent was identified as T. asahii by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). According to reported minimum inhibitory concentration (MIC) values, the infant received a high dose of fluconazole (FLC, 12 mg/kg, qod) and was successfully treated.Keywords: preterm, Trichosporon asahii, fluconazole, voriconazole, China |
first_indexed | 2024-04-11T07:06:03Z |
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id | doaj.art-c4fce8369bdd44719b9e87e44a1a7781 |
institution | Directory Open Access Journal |
issn | 1178-6973 |
language | English |
last_indexed | 2024-04-11T07:06:03Z |
publishDate | 2022-11-01 |
publisher | Dove Medical Press |
record_format | Article |
series | Infection and Drug Resistance |
spelling | doaj.art-c4fce8369bdd44719b9e87e44a1a77812022-12-22T04:38:23ZengDove Medical PressInfection and Drug Resistance1178-69732022-11-01Volume 156495649979460Trichosporon asahii Infection in an Extremely Preterm Infant in ChinaWang NTang JYWang ZWang LYSong TTLi BBWang LNa Wang1 *, Jing-yi Tang2 *, Zi Wang,3 Liu-yao Wang,4 Tian-tian Song,5 Bei-bei Li,5 Lin Wang5 1Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 2Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 3Department of Dermatology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, People’s Republic of China; 4Department of Pediatrics, Fuyong People’s Hospital, Shenzhen, People’s Republic of China; 5Department of Neonatology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Wang, Department of Neonatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email wl1894@yeah.netAbstract: Trichosporon asahii is an uncommon cause of fungal sepsis among neonates, but it is an important life-threatening opportunistic systemic pathogen. We report a case of T. asahii sepsis in a 980-g female baby born at 27 weeks of gestation. The extremely preterm initially presented with recurrent feeding intolerance and bloating; she subsequently developed oxygen saturation fluctuations, apnea, and a decreased heart rate. Blood culture was positive, and the causative agent was identified as T. asahii by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). According to reported minimum inhibitory concentration (MIC) values, the infant received a high dose of fluconazole (FLC, 12 mg/kg, qod) and was successfully treated.Keywords: preterm, Trichosporon asahii, fluconazole, voriconazole, Chinahttps://www.dovepress.com/trichosporon-asahii-infection-in-an-extremely-preterm-infant-in-china-peer-reviewed-fulltext-article-IDRpretermtrichosporon asahiifluconazolevoriconazolechina |
spellingShingle | Wang N Tang JY Wang Z Wang LY Song TT Li BB Wang L Trichosporon asahii Infection in an Extremely Preterm Infant in China Infection and Drug Resistance preterm trichosporon asahii fluconazole voriconazole china |
title | Trichosporon asahii Infection in an Extremely Preterm Infant in China |
title_full | Trichosporon asahii Infection in an Extremely Preterm Infant in China |
title_fullStr | Trichosporon asahii Infection in an Extremely Preterm Infant in China |
title_full_unstemmed | Trichosporon asahii Infection in an Extremely Preterm Infant in China |
title_short | Trichosporon asahii Infection in an Extremely Preterm Infant in China |
title_sort | trichosporon asahii infection in an extremely preterm infant in china |
topic | preterm trichosporon asahii fluconazole voriconazole china |
url | https://www.dovepress.com/trichosporon-asahii-infection-in-an-extremely-preterm-infant-in-china-peer-reviewed-fulltext-article-IDR |
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