Association between pretreatment lymphocyte count and efficacy of immune-enhancing therapy in acute necrotising pancreatitis: a post-hoc analysis of the multicentre, randomised, placebo-controlled TRACE trialResearch in context

Association between pretreatment lymphocyte count and efficacy of immune-enhancing therapy in acute necrotising pancreatitis: a post-hoc analysis of the multicentre, randomised, placebo-controlled TRACE trialResearch in context

Summary: Background: Immune-enhancing thymosin alpha 1 (Tα1) therapy may reduce infected pancreatic necrosis (IPN) in acute necrotising pancreatitis (ANP). However, the efficacy might be impacted by lymphocyte count due to the pharmacological action of Tα1. In this post-hoc analysis, we tested the...

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Bibliographic Details
Main Authors: Lu Ke, Wenjian Mao, Fang Shao, Jing Zhou, Minyi Xu, Tao Chen, Yuxiu Liu, Zhihui Tong, John Windsor, Penglin Ma, Weiqin Li, Wendi Jiang, He Zhang, Jiajia Lin, Mengjie Lu, Yan Chen, Mingmin Ma, Gang Li, Bo Ye, Baiqiang Li, Nonghua Lv, Yin Zhu, Liang Xia, Wenhua He, Zhenping, Chen, Xinting Pan, Qingyun Zhu, Youdong Wan, Hong Mei, Kang Li, Miao Chen, Chengjian He, Hongyi Yao, Zigui Zhu, Weili Gu, Weihua Lu, Jingyi Wu, Feng Zhou, Shumin Tu, Long Fu, Bingg Xue, Haibin Ni, Xiaofei Huang, Dandan Zhou, Guoxiu Zhang, Lening Ren, Dahuan Li, Xiangyang Zhao, Wei Zhao, Xiaomei Chen, Junli Sun, Keke Xin, Weiwei Chen, Qingcheng Xu, Jingchun Song, Qingbo Zeng, Min Shao, Dongsheng Zhao, Jianfeng Tu, Honggup Yang
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:EClinicalMedicine
Subjects:
Acute pancreatitis
Immunosuppression
Thymosin
Pancreatic necrosis
Infection
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023000925

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