The investigation of cytokines and oxidative stress in patients with systemic lupus erythematosus
Numerous factors can influence the onset of SLE and development of some clinical disease manifestations with various organ involvements and occurrence of characteristic symptoms and disease signs. This paper studies the balance between proinflammatory and antiinflammatory cytokines investigates the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2007-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470703231Z.pdf |
| _version_ | 1819236377213009920 |
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| author | Zvezdanović Lilika Đorđević Vidosava Ćosić Vladan Cvetković Tatjana Kundalić Slavica Stanković Aleksandra |
| author_facet | Zvezdanović Lilika Đorđević Vidosava Ćosić Vladan Cvetković Tatjana Kundalić Slavica Stanković Aleksandra |
| author_sort | Zvezdanović Lilika |
| collection | DOAJ |
| description | Numerous factors can influence the onset of SLE and development of some clinical disease manifestations with various organ involvements and occurrence of characteristic symptoms and disease signs. This paper studies the balance between proinflammatory and antiinflammatory cytokines investigates the presence of oxidative stress measuring certain prooxidative factors and determines the activation of antioxidative protection pathways aiming to establish possible correlations between the studied parameters. ELISA, enzymatic spectrophotometry and colorimetric methods were used to determine the above-mentioned parameters. The results obtained indicate that disturbed pro/antioxidative status is associated with the change of antioxidative factors, with the fall od SOD activity and increase of GPx and CAT activity in the erythrocytes of all studied groups of patients. At the same time, the cytokine production was altered, not only compared to the healthy control samples, but also in various clinical disease manifestations. Altered relationships of pro and antiinflammatory cytokines and the consequential disorders of other studied systems provide us with useful strategic targets for diagnostic monitoring and possible therapeutic interventions in SLE patients. |
| first_indexed | 2024-12-23T13:03:28Z |
| format | Article |
| id | doaj.art-c4fe7a5d5ab44d6caa116bc9009cf3ff |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-23T13:03:28Z |
| publishDate | 2007-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-c4fe7a5d5ab44d6caa116bc9009cf3ff2022-12-21T17:45:58ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662007-01-012632312400354-34470703231ZThe investigation of cytokines and oxidative stress in patients with systemic lupus erythematosusZvezdanović Lilika0Đorđević Vidosava1Ćosić Vladan2Cvetković Tatjana3Kundalić Slavica4Stanković Aleksandra5Centre of Medical Biochemistry, Clinical Centre, NišCentre of Medical Biochemistry, Clinical Centre, NišCentre of Medical Biochemistry, Clinical Centre, NišInstitute of Biochemistry, Faculty of Medicine, NišCentre of Medical Biochemistry, Clinical Centre, NišInstitute of Rheumatology, Niška BanjaNumerous factors can influence the onset of SLE and development of some clinical disease manifestations with various organ involvements and occurrence of characteristic symptoms and disease signs. This paper studies the balance between proinflammatory and antiinflammatory cytokines investigates the presence of oxidative stress measuring certain prooxidative factors and determines the activation of antioxidative protection pathways aiming to establish possible correlations between the studied parameters. ELISA, enzymatic spectrophotometry and colorimetric methods were used to determine the above-mentioned parameters. The results obtained indicate that disturbed pro/antioxidative status is associated with the change of antioxidative factors, with the fall od SOD activity and increase of GPx and CAT activity in the erythrocytes of all studied groups of patients. At the same time, the cytokine production was altered, not only compared to the healthy control samples, but also in various clinical disease manifestations. Altered relationships of pro and antiinflammatory cytokines and the consequential disorders of other studied systems provide us with useful strategic targets for diagnostic monitoring and possible therapeutic interventions in SLE patients.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470703231Z.pdfantioxidative enzymesautoimmune diseasescytokinessystemic lupus erythematosus |
| spellingShingle | Zvezdanović Lilika Đorđević Vidosava Ćosić Vladan Cvetković Tatjana Kundalić Slavica Stanković Aleksandra The investigation of cytokines and oxidative stress in patients with systemic lupus erythematosus Journal of Medical Biochemistry antioxidative enzymes autoimmune diseases cytokines systemic lupus erythematosus |
| title | The investigation of cytokines and oxidative stress in patients with systemic lupus erythematosus |
| title_full | The investigation of cytokines and oxidative stress in patients with systemic lupus erythematosus |
| title_fullStr | The investigation of cytokines and oxidative stress in patients with systemic lupus erythematosus |
| title_full_unstemmed | The investigation of cytokines and oxidative stress in patients with systemic lupus erythematosus |
| title_short | The investigation of cytokines and oxidative stress in patients with systemic lupus erythematosus |
| title_sort | investigation of cytokines and oxidative stress in patients with systemic lupus erythematosus |
| topic | antioxidative enzymes autoimmune diseases cytokines systemic lupus erythematosus |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470703231Z.pdf |
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