The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study
Purpose: Ocular blood flow (OBF) is an important risk factor for incidence, prevalence and progression of some ocular disorders. To date, there are very limited therapeutic options to increase OBF. This study investigated the effect of dobutamine on OBF of heathy adults using 3D pseudocontinuous art...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1003915/full |
| _version_ | 1811215739245297664 |
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| author | Linkun Cai Haijun Niu Pengling Ren Yawen Liu Tingting Zhang Dong Liu Erwei Zhao Liang Zhu Jing Li Penggang Qiao Wei Zheng Zhenchang Wang |
| author_facet | Linkun Cai Haijun Niu Pengling Ren Yawen Liu Tingting Zhang Dong Liu Erwei Zhao Liang Zhu Jing Li Penggang Qiao Wei Zheng Zhenchang Wang |
| author_sort | Linkun Cai |
| collection | DOAJ |
| description | Purpose: Ocular blood flow (OBF) is an important risk factor for incidence, prevalence and progression of some ocular disorders. To date, there are very limited therapeutic options to increase OBF. This study investigated the effect of dobutamine on OBF of heathy adults using 3D pseudocontinuous arterial spin labelling (3D-pcASL), and explored the risk factors associated with OBF.Methods: Forty-three healthy participants (86 eyes) were given an intravenous injection of dobutamine. We measured OBF using 3D-pcASL with a 3.0T- MRI scanner, OBF values were independently obtained by two doctors from the OBF map. We also collected physiological parameters using a vital signs monitor. The OBF and physiological parameters in the in the period before and after dobutamine injection states were obtained.Results: OBF increased significantly after dobutamine injection using paired t test method (from 22.43 ± 9.87 to 47.73 ± 14.02 ml/min/100g, p < 0.001). Age, heart rate and systolic blood pressure were the main risk factors affecting OBF using logistic regression analysis (all p values < 0.05).Conclusion: To the best of our knowledge, this is the first study observing the effect of dobutamine on OBF. Our findings indicated that intravenously injected dobutamine increased OBF, making it a possible option to counteract ocular vascular ischaemia in the future. |
| first_indexed | 2024-04-12T06:27:23Z |
| format | Article |
| id | doaj.art-c4fe8beaeab74b10a2cea14c685f724c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T06:27:23Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c4fe8beaeab74b10a2cea14c685f724c2022-12-22T03:44:06ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-11-011310.3389/fphys.2022.10039151003915The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling studyLinkun Cai0Haijun Niu1Pengling Ren2Yawen Liu3Tingting Zhang4Dong Liu5Erwei Zhao6Liang Zhu7Jing Li8Penggang Qiao9Wei Zheng10Zhenchang Wang11School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaDepartment of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaNational Space Science Center, Chinese Academy of Sciences, Beijing, ChinaNational Research Center for Rehabilitation Technical Aids, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaNational Space Science Center, Chinese Academy of Sciences, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaPurpose: Ocular blood flow (OBF) is an important risk factor for incidence, prevalence and progression of some ocular disorders. To date, there are very limited therapeutic options to increase OBF. This study investigated the effect of dobutamine on OBF of heathy adults using 3D pseudocontinuous arterial spin labelling (3D-pcASL), and explored the risk factors associated with OBF.Methods: Forty-three healthy participants (86 eyes) were given an intravenous injection of dobutamine. We measured OBF using 3D-pcASL with a 3.0T- MRI scanner, OBF values were independently obtained by two doctors from the OBF map. We also collected physiological parameters using a vital signs monitor. The OBF and physiological parameters in the in the period before and after dobutamine injection states were obtained.Results: OBF increased significantly after dobutamine injection using paired t test method (from 22.43 ± 9.87 to 47.73 ± 14.02 ml/min/100g, p < 0.001). Age, heart rate and systolic blood pressure were the main risk factors affecting OBF using logistic regression analysis (all p values < 0.05).Conclusion: To the best of our knowledge, this is the first study observing the effect of dobutamine on OBF. Our findings indicated that intravenously injected dobutamine increased OBF, making it a possible option to counteract ocular vascular ischaemia in the future.https://www.frontiersin.org/articles/10.3389/fphys.2022.1003915/fulldobutamine3D-pc ASLocular blood flowrisk factorshealthy adult |
| spellingShingle | Linkun Cai Haijun Niu Pengling Ren Yawen Liu Tingting Zhang Dong Liu Erwei Zhao Liang Zhu Jing Li Penggang Qiao Wei Zheng Zhenchang Wang The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study Frontiers in Physiology dobutamine 3D-pc ASL ocular blood flow risk factors healthy adult |
| title | The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study |
| title_full | The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study |
| title_fullStr | The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study |
| title_full_unstemmed | The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study |
| title_short | The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study |
| title_sort | effect of dobutamine on ocular blood flow of healthy adults a 3d pseudocontinuous aterial spin labelling study |
| topic | dobutamine 3D-pc ASL ocular blood flow risk factors healthy adult |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1003915/full |
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