Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering
Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here, we elucidate compensatory me...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-05-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00190/full |
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| author | Kevin Richard Sitek Kevin Richard Sitek Shanqing eCai Shanqing eCai Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Joseph S Perkell Joseph S Perkell Frank eGuenther Satrajit S Ghosh Satrajit S Ghosh |
| author_facet | Kevin Richard Sitek Kevin Richard Sitek Shanqing eCai Shanqing eCai Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Joseph S Perkell Joseph S Perkell Frank eGuenther Satrajit S Ghosh Satrajit S Ghosh |
| author_sort | Kevin Richard Sitek |
| collection | DOAJ |
| description | Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here, we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex. Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and orbitofrontal cortex may underlie successful compensatory mechanisms by more fluent stutterers. |
| first_indexed | 2024-12-18T23:01:54Z |
| format | Article |
| id | doaj.art-c4fec4ff3dab4858860ea7d9ee5b8153 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-18T23:01:54Z |
| publishDate | 2016-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-c4fec4ff3dab4858860ea7d9ee5b81532022-12-21T20:48:33ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612016-05-011010.3389/fnhum.2016.00190183800Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stutteringKevin Richard Sitek0Kevin Richard Sitek1Shanqing eCai2Shanqing eCai3Deryk Scott Beal4Deryk Scott Beal5Deryk Scott Beal6Deryk Scott Beal7Deryk Scott Beal8Joseph S Perkell9Joseph S Perkell10Frank eGuenther11Satrajit S Ghosh12Satrajit S Ghosh13Harvard UniversityMassachusetts Institute of TechnologyBoston UniversityMassachusetts Institute of TechnologyMassachusetts Institute of TechnologyBoston UniversityUniversity of TorontoUniversity of TorontoHolland Bloorview Kids Rehabilitation HospitalBoston UniversityMassachusetts Institute of TechnologyBoston UniversityHarvard UniversityMassachusetts Institute of TechnologyPersistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here, we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex. Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and orbitofrontal cortex may underlie successful compensatory mechanisms by more fluent stutterers.http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00190/fullStutteringMRIstructural connectivityresting state functional connectivitydiffusion weighted imaging (DWI) |
| spellingShingle | Kevin Richard Sitek Kevin Richard Sitek Shanqing eCai Shanqing eCai Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Deryk Scott Beal Joseph S Perkell Joseph S Perkell Frank eGuenther Satrajit S Ghosh Satrajit S Ghosh Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering Frontiers in Human Neuroscience Stuttering MRI structural connectivity resting state functional connectivity diffusion weighted imaging (DWI) |
| title | Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering |
| title_full | Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering |
| title_fullStr | Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering |
| title_full_unstemmed | Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering |
| title_short | Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering |
| title_sort | decreased cerebellar orbitofrontal connectivity correlates with stuttering severity whole brain functional and structural connectivity associations with persistent developmental stuttering |
| topic | Stuttering MRI structural connectivity resting state functional connectivity diffusion weighted imaging (DWI) |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00190/full |
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