Guidelines for the prevention of CMV transmisson by transfusion of blood components
Human cytomegalovirus can be transmitted by direct contact and iatrogenically by transfusion of blood components and by transplanted tissues or organs. After a primary, mostly asymptomatic infection, it remains latent in the body in CD34 + hematopoietic stem cells of the bone marrow and in periphera...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Medical Association
2013-06-01
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| Series: | Zdravniški Vestnik |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/646 |
| Summary: | Human cytomegalovirus can be transmitted by
direct contact and iatrogenically by transfusion
of blood components and by transplanted tissues
or organs. After a primary, mostly asymptomatic
infection, it remains latent in the body
in CD34 + hematopoietic stem cells of the bone
marrow and in peripheral blood monocytes.
Symptomatic CMV infection or viral reactivation
with involvement of different organs can
develop in immunocompromised patients. Prevention
of CMV transmission by transfusion of
blood components is important in patients at increased
risk: intrauterine and neonatal transfusions,
pregnant women, children with immune
deficiency, patients with hemopoietic progenitor
stem cell and organ transplants. The most important
approaches to the prevention of CMV transmission
are a selection of safe donors, serological
testing for CMV antibodies, leukodepletion,
pathogen inactivation, and rational use of blood.
None of these measures are 100 % efficient, but
they can complement each other. |
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| ISSN: | 1318-0347 1581-0224 |