Guidelines for the prevention of CMV transmisson by transfusion of blood components
Human cytomegalovirus can be transmitted by direct contact and iatrogenically by transfusion of blood components and by transplanted tissues or organs. After a primary, mostly asymptomatic infection, it remains latent in the body in CD34 + hematopoietic stem cells of the bone marrow and in periphera...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Medical Association
2013-06-01
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| Series: | Zdravniški Vestnik |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/646 |
| _version_ | 1819130678420176896 |
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| author | Marko Cukjati Vladan Rajić Darja Paro Panjan Irena Štucin Gantar Mojca Grošelj Grenc Urška Rahne Potokar Samo Zver |
| author_facet | Marko Cukjati Vladan Rajić Darja Paro Panjan Irena Štucin Gantar Mojca Grošelj Grenc Urška Rahne Potokar Samo Zver |
| author_sort | Marko Cukjati |
| collection | DOAJ |
| description | Human cytomegalovirus can be transmitted by
direct contact and iatrogenically by transfusion
of blood components and by transplanted tissues
or organs. After a primary, mostly asymptomatic
infection, it remains latent in the body
in CD34 + hematopoietic stem cells of the bone
marrow and in peripheral blood monocytes.
Symptomatic CMV infection or viral reactivation
with involvement of different organs can
develop in immunocompromised patients. Prevention
of CMV transmission by transfusion of
blood components is important in patients at increased
risk: intrauterine and neonatal transfusions,
pregnant women, children with immune
deficiency, patients with hemopoietic progenitor
stem cell and organ transplants. The most important
approaches to the prevention of CMV transmission
are a selection of safe donors, serological
testing for CMV antibodies, leukodepletion,
pathogen inactivation, and rational use of blood.
None of these measures are 100 % efficient, but
they can complement each other. |
| first_indexed | 2024-12-22T09:03:26Z |
| format | Article |
| id | doaj.art-c501650db46741da97072bbdbfd2ae35 |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-22T09:03:26Z |
| publishDate | 2013-06-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-c501650db46741da97072bbdbfd2ae352022-12-21T18:31:40ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242013-06-01826538Guidelines for the prevention of CMV transmisson by transfusion of blood componentsMarko CukjatiVladan RajićDarja Paro PanjanIrena Štucin GantarMojca Grošelj GrencUrška Rahne PotokarSamo ZverHuman cytomegalovirus can be transmitted by direct contact and iatrogenically by transfusion of blood components and by transplanted tissues or organs. After a primary, mostly asymptomatic infection, it remains latent in the body in CD34 + hematopoietic stem cells of the bone marrow and in peripheral blood monocytes. Symptomatic CMV infection or viral reactivation with involvement of different organs can develop in immunocompromised patients. Prevention of CMV transmission by transfusion of blood components is important in patients at increased risk: intrauterine and neonatal transfusions, pregnant women, children with immune deficiency, patients with hemopoietic progenitor stem cell and organ transplants. The most important approaches to the prevention of CMV transmission are a selection of safe donors, serological testing for CMV antibodies, leukodepletion, pathogen inactivation, and rational use of blood. None of these measures are 100 % efficient, but they can complement each other.http://vestnik.szd.si/index.php/ZdravVest/article/view/646 |
| spellingShingle | Marko Cukjati Vladan Rajić Darja Paro Panjan Irena Štucin Gantar Mojca Grošelj Grenc Urška Rahne Potokar Samo Zver Guidelines for the prevention of CMV transmisson by transfusion of blood components Zdravniški Vestnik |
| title | Guidelines for the prevention of CMV transmisson
by transfusion of blood components |
| title_full | Guidelines for the prevention of CMV transmisson
by transfusion of blood components |
| title_fullStr | Guidelines for the prevention of CMV transmisson
by transfusion of blood components |
| title_full_unstemmed | Guidelines for the prevention of CMV transmisson
by transfusion of blood components |
| title_short | Guidelines for the prevention of CMV transmisson
by transfusion of blood components |
| title_sort | guidelines for the prevention of cmv transmisson by transfusion of blood components |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/646 |
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