Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls
Research on spinal cord injuries is an important and living topic that raises many critical questions that need to be addressed. While numerous articles have compiled and compared various models of spinal cord injuries, there is limited comprehensive guide with clear instructions available for resea...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | MethodsX |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215016123002285 |
| _version_ | 1797796417704558592 |
|---|---|
| author | Arman Vahabi Anıl Murat Öztürk |
| author_facet | Arman Vahabi Anıl Murat Öztürk |
| author_sort | Arman Vahabi |
| collection | DOAJ |
| description | Research on spinal cord injuries is an important and living topic that raises many critical questions that need to be addressed. While numerous articles have compiled and compared various models of spinal cord injuries, there is limited comprehensive guide with clear instructions available for researchers who are unfamiliar with clip compression model. This model creates acute compression damage in spinal cord, which aims to mimic the nature of traumatic spinal cord damage in humans. Purpose of this article is to share our experience on clip compression model, with experience gained from more than 150 animals, and to provide guidance for researchers with lack of experience who wish to design studies with this model. We have defined several key variables, as well as the difficulties that may arise when applying this model. − Proper preparation, good infrastructure and necessary tools and knowledge of anatomy related is essential to the success of this model. − Good exposure with non-bleeding surgical site is key factor for surgical step. − Postoperative care is particularly challenging, and researchers should consider extending their studies over a reasonable time period to ensure that appropriate care could be provided. |
| first_indexed | 2024-03-13T03:32:47Z |
| format | Article |
| id | doaj.art-c50352a9c7bb4f918b7099414b8d19f6 |
| institution | Directory Open Access Journal |
| issn | 2215-0161 |
| language | English |
| last_indexed | 2024-03-13T03:32:47Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | MethodsX |
| spelling | doaj.art-c50352a9c7bb4f918b7099414b8d19f62023-06-24T05:17:48ZengElsevierMethodsX2215-01612023-01-0110102231Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfallsArman Vahabi0Anıl Murat Öztürk1Corresponding author.; Department of Orthopaedics and Traumatology, Ege University School of Medicine, Izmir, TurkeyDepartment of Orthopaedics and Traumatology, Ege University School of Medicine, Izmir, TurkeyResearch on spinal cord injuries is an important and living topic that raises many critical questions that need to be addressed. While numerous articles have compiled and compared various models of spinal cord injuries, there is limited comprehensive guide with clear instructions available for researchers who are unfamiliar with clip compression model. This model creates acute compression damage in spinal cord, which aims to mimic the nature of traumatic spinal cord damage in humans. Purpose of this article is to share our experience on clip compression model, with experience gained from more than 150 animals, and to provide guidance for researchers with lack of experience who wish to design studies with this model. We have defined several key variables, as well as the difficulties that may arise when applying this model. − Proper preparation, good infrastructure and necessary tools and knowledge of anatomy related is essential to the success of this model. − Good exposure with non-bleeding surgical site is key factor for surgical step. − Postoperative care is particularly challenging, and researchers should consider extending their studies over a reasonable time period to ensure that appropriate care could be provided.http://www.sciencedirect.com/science/article/pii/S2215016123002285RatRodentSpine injuryNerve injuryAnimal experiment |
| spellingShingle | Arman Vahabi Anıl Murat Öztürk Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls MethodsX Rat Rodent Spine injury Nerve injury Animal experiment |
| title | Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls |
| title_full | Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls |
| title_fullStr | Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls |
| title_full_unstemmed | Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls |
| title_short | Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls |
| title_sort | conducting spinal cord injury model with clip compression in rodents pearls and pitfalls |
| topic | Rat Rodent Spine injury Nerve injury Animal experiment |
| url | http://www.sciencedirect.com/science/article/pii/S2215016123002285 |
| work_keys_str_mv | AT armanvahabi conductingspinalcordinjurymodelwithclipcompressioninrodentspearlsandpitfalls AT anılmuratozturk conductingspinalcordinjurymodelwithclipcompressioninrodentspearlsandpitfalls |