A case of neuronal intranuclear inclusion disease associated with lupus nephritis–like nephropathy

Neuronal intranuclear inclusion disease (NIID) is a relatively new entity identified as a progressive neurodegenerative disease characterised by eosinophilic hyaline intranuclear inclusions widely observed in neuronal and somatic cells. Renal biopsy from one of our patients with NIID showed lupus ne...

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Main Authors: Taro Horino, Tatsuki Matsumoto, Kosuke Inoue, Osamu Ichii, Yoshio Terada
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:eNeurologicalSci
Online Access:http://www.sciencedirect.com/science/article/pii/S2405650218300029
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author Taro Horino
Tatsuki Matsumoto
Kosuke Inoue
Osamu Ichii
Yoshio Terada
author_facet Taro Horino
Tatsuki Matsumoto
Kosuke Inoue
Osamu Ichii
Yoshio Terada
author_sort Taro Horino
collection DOAJ
description Neuronal intranuclear inclusion disease (NIID) is a relatively new entity identified as a progressive neurodegenerative disease characterised by eosinophilic hyaline intranuclear inclusions widely observed in neuronal and somatic cells. Renal biopsy from one of our patients with NIID showed lupus nephritis–like pathology. He was treated with steroids and angiotensin-converting enzyme inhibitors and his proteinuria improved. The present case highlights that immune-mediated glomerulonephritis can be a presenting feature of NIID, which can be controlled with proper treatment. Keywords: Neuronal intranuclear inclusion disease, Lupus nephritis–like nephropathy
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spelling doaj.art-c5042c79a2644331ad5488dd2d9838a62022-12-21T21:58:06ZengElseviereNeurologicalSci2405-65022018-03-01102830A case of neuronal intranuclear inclusion disease associated with lupus nephritis–like nephropathyTaro Horino0Tatsuki Matsumoto1Kosuke Inoue2Osamu Ichii3Yoshio Terada4Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan; Corresponding author at: Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan.Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, JapanDepartment of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, JapanLaboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, JapanDepartment of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, JapanNeuronal intranuclear inclusion disease (NIID) is a relatively new entity identified as a progressive neurodegenerative disease characterised by eosinophilic hyaline intranuclear inclusions widely observed in neuronal and somatic cells. Renal biopsy from one of our patients with NIID showed lupus nephritis–like pathology. He was treated with steroids and angiotensin-converting enzyme inhibitors and his proteinuria improved. The present case highlights that immune-mediated glomerulonephritis can be a presenting feature of NIID, which can be controlled with proper treatment. Keywords: Neuronal intranuclear inclusion disease, Lupus nephritis–like nephropathyhttp://www.sciencedirect.com/science/article/pii/S2405650218300029
spellingShingle Taro Horino
Tatsuki Matsumoto
Kosuke Inoue
Osamu Ichii
Yoshio Terada
A case of neuronal intranuclear inclusion disease associated with lupus nephritis–like nephropathy
eNeurologicalSci
title A case of neuronal intranuclear inclusion disease associated with lupus nephritis–like nephropathy
title_full A case of neuronal intranuclear inclusion disease associated with lupus nephritis–like nephropathy
title_fullStr A case of neuronal intranuclear inclusion disease associated with lupus nephritis–like nephropathy
title_full_unstemmed A case of neuronal intranuclear inclusion disease associated with lupus nephritis–like nephropathy
title_short A case of neuronal intranuclear inclusion disease associated with lupus nephritis–like nephropathy
title_sort case of neuronal intranuclear inclusion disease associated with lupus nephritis like nephropathy
url http://www.sciencedirect.com/science/article/pii/S2405650218300029
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