Physical Obstruction of Nasal Cavities With Subsequent Asphyxia, Causes Lethality of Rats in an Acute Inhalation Study With Hydrophobic HMDZ Surface-Treated Synthetic Amorphous Silica (SAS)

Physical Obstruction of Nasal Cavities With Subsequent Asphyxia, Causes Lethality of Rats in an Acute Inhalation Study With Hydrophobic HMDZ Surface-Treated Synthetic Amorphous Silica (SAS)

The aim of the present study was to understand the mechanism of lethality associated with high dose inhalation of a low-density hydrophobic surface-treated SAS observed in some acute inhalation studies. It was demonstrated that physical obstruction of the upper respiratory tract (nasal cavities) cau...

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Bibliographic Details
Main Authors: Nils Krueger, Klaus Weber, Nils Warfving, Alex Vitali, Jürgen Nolde, Tobias B. Schuster, Gustav Gerd Bruer, Otto Creutzenberg, Benno Wessely, Michael Stintz, Valerie Moise, Marco Kellert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Public Health
Subjects:
synthetic amorphous silica
inhalation
rat
contact angle
physical obstruction
suffocation
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2022.907078/full

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