Impaired Expression of Cytoplasmic Actins Leads to Chromosomal Instability of MDA-MB-231 Basal-Like Mammary Gland Cancer Cell Line

Impaired Expression of Cytoplasmic Actins Leads to Chromosomal Instability of MDA-MB-231 Basal-Like Mammary Gland Cancer Cell Line

We have shown previously that two cytoplasmic actin isoforms play different roles in neoplastic cell transformation. Namely, β-cytoplasmic actin acts as a tumor suppressor, whereas γ-cytoplasmic actin enhances malignant features of tumor cells. The distinct participation of each cytoplasmic actin in...

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Bibliographic Details
Main Authors: Vera Dugina, Galina Shagieva, Mariya Novikova, Svetlana Lavrushkina, Olga Sokova, Igor Kireev, Pavel Kopnin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
mammary gland cancer
actin isoforms
chromosomal instability (CIN)
Online Access:https://www.mdpi.com/1420-3049/26/8/2151

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