Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review)
The ketogenic diet (KD) has been important in treating epilepsy since the 1920s. The benefits of KD further expanded to other neurological diseases, including Alzheimer’s diseases, autism spectrum disorder, and nutritional disorder (obesity). Although the therapeutic efficacy of KD has been generall...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3566 |
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| author | Jun-Ming Lim Vengadesh Letchumanan Loh Teng-Hern Tan Kar-Wai Hong Sunny-Hei Wong Nurul-Syakima Ab Mutalib Learn-Han Lee Jodi Woan-Fei Law |
| author_facet | Jun-Ming Lim Vengadesh Letchumanan Loh Teng-Hern Tan Kar-Wai Hong Sunny-Hei Wong Nurul-Syakima Ab Mutalib Learn-Han Lee Jodi Woan-Fei Law |
| author_sort | Jun-Ming Lim |
| collection | DOAJ |
| description | The ketogenic diet (KD) has been important in treating epilepsy since the 1920s. The benefits of KD further expanded to other neurological diseases, including Alzheimer’s diseases, autism spectrum disorder, and nutritional disorder (obesity). Although the therapeutic efficacy of KD has been generally accepted, there is limited knowledge about its underlying mechanism of action, particularly its effect on our gut microbiome. Gut dysbiosis has been proposed to be involved in those diseases, and KD can promote gut microbiota remodeling that may assist in recovery. This review explores the therapeutic applications of KD, the roles of the gut microbiome in neurological diseases and obesity, as well as the effect of KD on the gut microbiome. The present information suggests that KD has significant roles in altering the gut microbiome to improve disease symptoms, mainly by incrementing <i>Bacteroidetes</i> to <i>Firmicutes</i> (B/F) ratio and reducing <i>Proteobacteria</i> in certain cases. However, current gaps call for continued research to understand better the gut microbiota profile altered by KD. |
| first_indexed | 2024-03-10T01:25:08Z |
| format | Article |
| id | doaj.art-c5080d720f7a45848a3344b1c11b1a68 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:25:08Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c5080d720f7a45848a3344b1c11b1a682023-11-23T13:52:41ZengMDPI AGNutrients2072-66432022-08-011417356610.3390/nu14173566Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review)Jun-Ming Lim0Vengadesh Letchumanan1Loh Teng-Hern Tan2Kar-Wai Hong3Sunny-Hei Wong4Nurul-Syakima Ab Mutalib5Learn-Han Lee6Jodi Woan-Fei Law7Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaThe ketogenic diet (KD) has been important in treating epilepsy since the 1920s. The benefits of KD further expanded to other neurological diseases, including Alzheimer’s diseases, autism spectrum disorder, and nutritional disorder (obesity). Although the therapeutic efficacy of KD has been generally accepted, there is limited knowledge about its underlying mechanism of action, particularly its effect on our gut microbiome. Gut dysbiosis has been proposed to be involved in those diseases, and KD can promote gut microbiota remodeling that may assist in recovery. This review explores the therapeutic applications of KD, the roles of the gut microbiome in neurological diseases and obesity, as well as the effect of KD on the gut microbiome. The present information suggests that KD has significant roles in altering the gut microbiome to improve disease symptoms, mainly by incrementing <i>Bacteroidetes</i> to <i>Firmicutes</i> (B/F) ratio and reducing <i>Proteobacteria</i> in certain cases. However, current gaps call for continued research to understand better the gut microbiota profile altered by KD.https://www.mdpi.com/2072-6643/14/17/3566dietary therapiesnutritiondietgut microbiotaintestinal microbesmicrobiome |
| spellingShingle | Jun-Ming Lim Vengadesh Letchumanan Loh Teng-Hern Tan Kar-Wai Hong Sunny-Hei Wong Nurul-Syakima Ab Mutalib Learn-Han Lee Jodi Woan-Fei Law Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review) Nutrients dietary therapies nutrition diet gut microbiota intestinal microbes microbiome |
| title | Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review) |
| title_full | Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review) |
| title_fullStr | Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review) |
| title_full_unstemmed | Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review) |
| title_short | Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review) |
| title_sort | ketogenic diet a dietary intervention via gut microbiome modulation for the treatment of neurological and nutritional disorders a narrative review |
| topic | dietary therapies nutrition diet gut microbiota intestinal microbes microbiome |
| url | https://www.mdpi.com/2072-6643/14/17/3566 |
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