Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
Peptide-based filamentous assemblies are successfully used for generation of structurally ordered materials, but their de novo design and structural characterization is challenging. Here, the authors provide a strategy for the design of self-assembling peptide nanotubes based on modifications of an...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20689-w |
| _version_ | 1818735830944972800 |
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| author | Fengbin Wang Ordy Gnewou Charles Modlin Leticia C. Beltran Chunfu Xu Zhangli Su Puneet Juneja Gevorg Grigoryan Edward H. Egelman Vincent P. Conticello |
| author_facet | Fengbin Wang Ordy Gnewou Charles Modlin Leticia C. Beltran Chunfu Xu Zhangli Su Puneet Juneja Gevorg Grigoryan Edward H. Egelman Vincent P. Conticello |
| author_sort | Fengbin Wang |
| collection | DOAJ |
| description | Peptide-based filamentous assemblies are successfully used for generation of structurally ordered materials, but their de novo design and structural characterization is challenging. Here, the authors provide a strategy for the design of self-assembling peptide nanotubes based on modifications of an arginine clasp interaction motif, and report the cryo-EM structures of seven designed nanotubes. |
| first_indexed | 2024-12-18T00:27:30Z |
| format | Article |
| id | doaj.art-c50837dc2bd4499eb00831a096021fb5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:27:30Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c50837dc2bd4499eb00831a096021fb52022-12-21T21:27:13ZengNature PortfolioNature Communications2041-17232021-01-0112111410.1038/s41467-020-20689-wStructural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterialsFengbin Wang0Ordy Gnewou1Charles Modlin2Leticia C. Beltran3Chunfu Xu4Zhangli Su5Puneet Juneja6Gevorg Grigoryan7Edward H. Egelman8Vincent P. Conticello9Department of Biochemistry and Molecular Genetics, University of VirginiaDepartment of Chemistry, Emory UniversityDepartment of Chemistry, Emory UniversityDepartment of Biochemistry and Molecular Genetics, University of VirginiaDepartment of Chemistry, Emory UniversityDepartment of Biochemistry and Molecular Genetics, University of VirginiaThe Robert P. Apkarian Integrated Electron Microscopy Core (IEMC), Emory UniversityDepartment of Computer Science, Dartmouth CollegeDepartment of Biochemistry and Molecular Genetics, University of VirginiaDepartment of Chemistry, Emory UniversityPeptide-based filamentous assemblies are successfully used for generation of structurally ordered materials, but their de novo design and structural characterization is challenging. Here, the authors provide a strategy for the design of self-assembling peptide nanotubes based on modifications of an arginine clasp interaction motif, and report the cryo-EM structures of seven designed nanotubes.https://doi.org/10.1038/s41467-020-20689-w |
| spellingShingle | Fengbin Wang Ordy Gnewou Charles Modlin Leticia C. Beltran Chunfu Xu Zhangli Su Puneet Juneja Gevorg Grigoryan Edward H. Egelman Vincent P. Conticello Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials Nature Communications |
| title | Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials |
| title_full | Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials |
| title_fullStr | Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials |
| title_full_unstemmed | Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials |
| title_short | Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials |
| title_sort | structural analysis of cross α helical nanotubes provides insight into the designability of filamentous peptide nanomaterials |
| url | https://doi.org/10.1038/s41467-020-20689-w |
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